Spemann's organizer and self-regulation in amphibian embryos

被引：186
作者：
De Robertis, EM [1 ]
机构：
[1] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90095 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 04期
关键词：
D O I：
10.1038/nrm1855
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In 1924, Spemann and Mangold demonstrated the induction of Siamese twins in transplantation experiments with salamander eggs. Recent work in amphibian embryos has followed their lead and uncovered that cells in signalling centres that are located at the dorsal and ventral poles of the gastrula embryo communicate with each other through a network of secreted growth-factor antagonists, a protease that degrades them, a protease inhibitor and bone-morphogenic-protein signals.
引用
收藏
页码：296 / 302
页数：8
相关论文
共 60 条
[1]   The organizer factors Chordin and Noggin are required for mouse forebrain development [J].
Bachiller, D ;
Klingensmith, J ;
Kemp, C ;
Belo, JA ;
Anderson, RM ;
May, SR ;
McMahon, JA ;
McMahon, AP ;
Harland, RM ;
Rossant, J ;
De Robertis, EM .
NATURE, 2000, 403 (6770) :658-661
[2]   Neural differentiation without organizer [J].
Barth, LG .
JOURNAL OF EXPERIMENTAL ZOOLOGY, 1941, 87 (03) :371-383
[3]   Experiments for the analysis of induction substances in embryonal development. [J].
Bautzmann, H ;
Holtfreter, J ;
Spemann, H ;
Mangold, O .
NATURWISSENSCHAFTEN, 1932, 20 :971-972
[4]   Axis development and early asymmetry in mammals [J].
Beddington, RSP ;
Robertson, EJ .
CELL, 1999, 96 (02) :195-209
[5]   Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer [J].
Bouwmeester, T ;
Kim, SH ;
Sasai, Y ;
Lu, B ;
DeRobertis, EM .
NATURE, 1996, 382 (6592) :595-601
[6]   CLONING OF AN X-LAEVIS GENE EXPRESSED DURING EARLY EMBRYOGENESIS CODING FOR A PEPTIDE REGION HOMOLOGOUS TO DROSOPHILA HOMEOTIC GENES [J].
CARRASCO, AE ;
MCGINNIS, W ;
GEHRING, WJ ;
DEROBERTIS, EM .
CELL, 1984, 37 (02) :409-414
[7]   MOLECULAR NATURE OF SPEMANNS ORGANIZER - THE ROLE OF THE XENOPUS HOMEOBOX GENE GOOSECOID [J].
CHO, KWY ;
BLUMBERG, B ;
STEINBEISSER, H ;
DEROBERTIS, EM .
CELL, 1991, 67 (06) :1111-1120
[8]   The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm [J].
Collavin, L ;
Kirschner, MW .
DEVELOPMENT, 2003, 130 (04) :805-816
[9]   Xolloid-related:: a novel BMP1/Tolloid-related metalloprotease is expressed during early Xenopus development [J].
Dale, L ;
Evans, W ;
Goodman, SA .
MECHANISMS OF DEVELOPMENT, 2002, 119 (02) :177-190
[10]   Dorsal-ventral patterning and neural induction in Xenopus embryos [J].
De Robertis, EM ;
Kuroda, H .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2004, 20 :285-308
123456