Antifungal Effect and Inhibition of the Virulence Mechanism of D-Limonene against Candida parapsilosis

被引：13

作者：

Leite-Andrade, Melyna Chaves ^{[1
]}

de Araujo Neto, Luiz Nascimento ^{[2
]}

Silva Buonafina-Paz, Maria Daniela ^{[2
]}

Graciano dos Santos, Franz de Assis ^{[2
]}

da Silva Alves, Adryelle Idalina ^{[1
]}

Accioly Brelaz de Castro, Maria Carolina ^{[3
]}

Mori, Edna ^{[4
]}

Goncalves Vasconcelos de Lacerda, Bruna Caroline ^{[4
]}

Araujo, Isaac Moura ^{[5
]}

Melo Coutinho, Henrique Douglas ^{[5
]}

Kowalska, Grazyna ^{[6
]}

Kowalski, Radoslaw ^{[7
]}

Baj, Tomasz ^{[8
]}

Neves, Rejane Pereira ^{[2
]}

机构：

[1] Univ Fed Pernambuco UFPE, Dept Med Trop, BR-50670901 Recife, PE, Brazil

[2] Univ Fed Pernambuco UFPE, Dept Micol, BR-50670901 Recife, PE, Brazil

[3] Univ Fed Pernambuco UFPE, Ctr Acad Vitoria, Lab Parasitol & Lab Imunol IAM, BR-63024015 Vitoria De Santo Antao, PE, Brazil

[4] Fac CECAPE Coll, BR-63024015 Juazeiro Do Norte, CE, Brazil

[5] Univ Reg Cariri, Dept Quim Biol, BR-63105010 Crato, CE, Brazil

[6] Univ Life Sci Lublin, Dept Tourism & Recreat, 15 Akad Str, PL-20950 Lublin, Poland

[7] Univ Life Sci Lublin, Dept Anal & Food Qual Assessment, 8 Skromna Str, PL-20704 Lublin, Poland

[8] Med Univ Lublin, Dept Pharmacognosy Med Plants Garden, 1 Chodzki Str, PL-20093 Lublin, Poland

来源：

MOLECULES | 2022年 / 27卷 / 24期

关键词：

adherence; Candida parapsilosis; mechanism of action; morphogenesis; terpenoid; INDUCED APOPTOSIS; ESSENTIAL OIL; SUSCEPTIBILITY; ADHERENCE; GROWTH; CELLS;

D O I：

10.3390/molecules27248884

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Yeasts from the Candida parapsilosis complex are clinically relevant due to their high virulence and pathogenicity potential, such as adherence to epithelial cells and emission of filamentous structures, as well as their low susceptibility to antifungals. D-limonene, a natural compound, emerges as a promising alternative with previously described antibacterial, antiparasitic, and antifungal activity; however, its mechanisms of action and antivirulence activity against C. parapsilosis complex species have not been elucidated. Therefore, in the present study, we aimed to evaluate the antifungal and antivirulence action, as well as the mechanism of action of D-limonene against isolates from this complex. D-limonene exhibited relevant antifungal activity against C. parapsilosis complex yeasts, as well as excellent antivirulence activity by inhibiting yeast morphogenesis and adherence to the human epithelium. Furthermore, the apoptotic mechanism induced by this compound, which is not induced by oxidative stress, represents an important target for the development of new antifungal drugs.

引用

页数：12

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