Assessment of the Efficacy of Joint Lavage in Rabbits with Osteoarthritis of the Knee

被引:19
作者
Fu, Xin [1 ]
Lin, Lin [1 ]
Zhang, Jiying [1 ]
Yu, Changlong [1 ]
机构
[1] Peking Univ, Inst Sport Med, Hosp 3, Beijing 100083, Peoples R China
关键词
osteoarthritis; Joint lavage; articular cartilage; synovium; IL-1; beta; TNF-alpha; INTERLEUKIN-1 RECEPTOR ANTAGONIST; CONTROLLED TRIAL; ARTHROSCOPIC SURGERY; SUPPRESSION; CORTICOSTEROIDS; MANAGEMENT; ARTHRITIS; PLACEBO;
D O I
10.1002/jor.20720
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
We investigated the efficacy of joint lavage to alter the progression of the disease process in a rabbit model of knee OA in varying stages of the disease. Thirty-three white rabbits were operated to induce OA, and them the rabbits were divided into three groups (10 in each) randomly. In group 1, on week 1 after the operation, joint lavage was performed on both knees in five rabbits as treatment group, and the other five rabbits were used as control group received no intervention. By the end of week 2 after operation, the rabbits were sacrificed. In group 2, five received joint lavage on week 2, and all were sacrificed on week 3. In group 3, five received joint lavage on week 3, and all were sacrificed on week 4. In each group, histological evaluation showed that both the breakdown of articular cartilage and the inflammation of synovium were less in the knees treated with joint, lavage than that in the control knees. The enzyme-linked immunosorbent assay revealed that the expression of IL-1 beta and TNF-alpha in synovial fluid decreased significantly in the treatment group. Our findings suggested that Joint lavage was beneficial for OA at different phases of OA in rabbit models. Joint lavage may be a beneficial method for the treatment of OA clinically. (C) 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:91-96, 2009
引用
收藏
页码:91 / 96
页数:6
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