Hippo-YAP and mTOR pathways collaborate to regulate organ size

被引：73

作者：

Csibi, Alfred ^{[1
]}

Blenis, John ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

NATURE CELL BIOLOGY | 2012年 / 14卷 / 12期

关键词：

SIGNALING PATHWAY; GROWTH-CONTROL; INHIBITION;

D O I：

10.1038/ncb2634

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Regulation of organ size is achieved through the action of the mTOR and Hippo signalling pathways, which control cell proliferation and cell growth in response to extracellular cues. A link between these pathways is revealed by the finding that YAP downregulates PTEN to promote cell growth and tissue hyperplasia.

引用

页码：1244 / 1245

页数：2

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