Boronic acid-based fluorescent receptors for selective recognition of thymine glycol

被引：24

作者：

Luvino, Delphine ^{[1
]}

Gasparutto, Didier ^{[2
]}

Reynaud, Sandra ^{[2
]}

Smietana, Michael ^{[1
]}

Vasseur, Jean-Jacques ^{[1
]}

机构：

[1] Univ Montpellier 2, Inst Biomol Max Mousseron, CNRS, Univ Montpellier 1,UMR 5247, F-34095 Montpellier, France

[2] CEA Grenoble, INAC, CEA UJF, Lab Les Acides Nucl,Serv Chim Inorgan Biol,UMR E3, Grenoble, France

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 42期

关键词：

thymine glycol; oxidative DNA lesion; fluorescence detection; boronic acids; tumor markers;

D O I：

10.1016/j.tetlet.2008.07.173

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Thymine glycol is the major oxidation product of thymine. The amount of thymine glycol present within cellular DNA is one marker of the extent of oxidative damage, and chemosensors for thymine glycol have therefore a number of potential applications. In continuation of our studies devoted to the detection of modified nucleosides, we report herein our results toward the fluorescence detection of thymine glycol at both the nucleoside and the oligonucleotide levels using boronic acid sensors. These receptors show significant fluorescence enhancements and high selectivities in aqueous conditions upon binding with thymine glycol. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6075 / 6078

页数：4

共 31 条

[1] OXIDATIVE DAMAGE TO DNA - RELATION TO SPECIES METABOLIC-RATE AND LIFE-SPAN [J].