Research Progress in Atopic March

被引:130
作者
Yang, Lan [1 ]
Fu, Jinrong [1 ]
Zhou, Yufeng [1 ,2 ]
机构
[1] Fudan Univ, Shanghai Key Lab Med Epigenet, Int Colab Med Epigenet & Metab,Inst Biomed Sci, Inst Pediat,Childrens Hosp,Minist Sci & Technol, Shanghai, Peoples R China
[2] Fudan Univ, Natl Hlth Commiss NHC, Key Lab Neonatal Dis, Shanghai, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
atopic dermatitis; asthma; food allergy; allergic rhinitis; atopic march; THYMIC STROMAL LYMPHOPOIETIN; OF-FUNCTION MUTATIONS; COWS MILK ALLERGY; FOOD ALLERGY; GUT MICROBIOTA; EOSINOPHILIC ESOPHAGITIS; SKIN BARRIER; DOUBLE-BLIND; FOLLOW-UP; SUBLINGUAL IMMUNOTHERAPY;
D O I
10.3389/fimmu.2020.01907
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The incidence of allergic diseases continues to rise. Cross-sectional and longitudinal studies have indicated that allergic diseases occur in a time-based order: from atopic dermatitis and food allergy in infancy to gradual development into allergic asthma and allergic rhinitis in childhood. This phenomenon is defined as the "atopic march". Some scholars have suggested that the atopic march does not progress completely in a temporal pattern with genetic and environmental factors. Also, the mechanisms underlying the atopic march are incompletely understood. Nevertheless, the concept of the atopic march provides a new perspective for the mechanistic research, prediction, prevention, and treatment of atopic diseases. Here, we review the epidemiology, related diseases, mechanistic studies, and treatment strategies for the atopic march.
引用
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页数:11
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