The first chemoselective tandem acylation of the Blaise reaction intermediate: a novel method for the synthesis of α-acyl-β-enamino esters, key intermediate for pyrazoles

被引：54

作者：

Chun, Yu Sung ^{[2
]}

Lee, Ki Kon ^{[1
]}

Ko, Young Ok ^{[2
]}

Shin, Hyunik ^{[1
]}

Lee, Sang-gi ^{[2
]}

机构：

[1] LG Life Sci LTd, R&D, Chem Dev Div, Taejon 305380, South Korea

[2] Ewha Womans Univ, Dept Chem & Nano Sci BK21, Seoul 120750, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 41期

关键词：

D O I：

10.1039/b813369g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Blaise reaction intermediate, a zinc bromide complex of beta-enamino ester, could be activated in situ by addition of a stoichiometric or catalytic amount of n-BuLi to allow chemoselective tandem C2-acylation providing alpha-acyl-beta-enamino esters, which are valuable intermediates for the syntheses of tri- and tetrasubstituted pyrazoles.

引用

页码：5098 / 5100

页数：3

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