Amino Acid Signaling in High Definition

被引：5

作者：

Gaubitz, Christl ^{[1
]}

Loewith, Robbie ^{[1
,2
,3
]}

机构：

[1] Univ Geneva, Dept Mol Biol, CH-1211 Geneva, Switzerland

[2] Univ Geneva, Natl Ctr Competence Res, CH-1211 Geneva, Switzerland

[3] Univ Geneva, Natl Ctr Frontiers Genet & Chem Biol, CH-1211 Geneva, Switzerland

来源：

STRUCTURE | 2012年 / 20卷 / 12期

关键词：

TRANSFER-RNA SYNTHETASE; CRYSTAL-STRUCTURE; COMPLEX REVEALS; CONTROLS TORC1; EGO COMPLEX; ACTIVATION; RAGULATOR; GTPASES; MTORC1; GEF;

D O I：

10.1016/j.str.2012.11.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：1993 / 1994

页数：2

共 12 条

[1] Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels tomTORC1 [J].

Bar-Peled, Liron ;

Schweitzer, Lawrence D. ;

Zoncu, Roberto ;

Sabatini, David M. .

CELL, 2012, 150 (06) :1196-1208

[2] The Vam6 GEF Controls TORC1 by Activating the EGO Complex [J].

Binda, Matteo ;

Peli-Gulli, Marie-Pierre ;

Bonfils, Gregory ;

Panchaud, Nicolas ;

Urban, Joerg ;

Sturgill, Thomas W. ;

Loewith, Robbie ;

De Virgilio, Claudio .

MOLECULAR CELL, 2009, 35 (05) :563-573

[3] Leucyl-tRNA Synthetase Controls TORC1 via the EGO Complex [J].

Bonfils, Gregory ;

Jaquenoud, Malika ;

Bontron, Severine ;

Ostrowicz, Clemens ;

Ungermann, Christian ;

De Virgilio, Claudio .

MOLECULAR CELL, 2012, 46 (01) :105-110

[4] Glutaminolysis Activates Rag-mTORC1 Signaling [J].

Duran, Raul V. ;

Oppliger, Wolfgang ;

Robitaille, Aaron M. ;

Heiserich, Lisa ;

Skendaj, Roswitha ;

Gottlieb, Eyal ;

Hall, Michael N. .

MOLECULAR CELL, 2012, 47 (03) :349-358

[5] Regulation of TOR by small GTPases [J].

Duran, Raul V. ;

Hall, Michael N. .

EMBO REPORTS, 2012, 13 (02) :121-128

[6] Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation [J].

Gong, Rui ;

Li, Li ;

Liu, Yi ;

Wang, Ping ;

Yang, Huirong ;

Wang, Ling ;

Cheng, Jingdong ;

Guan, Kun-Liang ;

Xu, Yanhui .

GENES & DEVELOPMENT, 2011, 25 (16) :1668-1673

[7] Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway [J].

Han, Jung Min ;

Jeong, Seung Jae ;

Park, Min Chul ;

Kim, Gyuyoup ;

Kwon, Nam Hoon ;

Kim, Hoi Kyoung ;

Ha, Sang Hoon ;

Ryu, Sung Ho ;

Kim, Sunghoon .

CELL, 2012, 149 (02) :410-424

[8] Crystal Structure of the Gtr1pGTP-Gtr2pGDP Protein Complex Reveals Large Structural Rearrangements Triggered by GTP-to-GDP Conversion [J].

Jeong, Jae-Hee ;

Lee, Kwang-Hoon ;

Kim, Young-Mi ;

Kim, Do-Hyung ;

Oh, Byung-Ha ;

Kim, Yeon-Gil .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (35) :29648-29653

[9] Structural Conservation of Components in the Amino Acid Sensing Branch of the TOR Pathway in Yeast and Mammals [J].

Kogan, Konstantin ;

Spear, Eric D. ;

Kaiser, Chris A. ;

Fass, Deborah .

JOURNAL OF MOLECULAR BIOLOGY, 2010, 402 (02) :388-398

[10] Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids [J].

Sancak, Yasemin ;

Bar-Peled, Liron ;

Zoncu, Roberto ;

Markhard, Andrew L. ;

Nada, Shigeyuki ;

Sabatini, David M. .

CELL, 2010, 141 (02) :290-303

← 1 2 →