The molecular mechanism of conformational changes of the triplet prion fibrils for pH

被引：11

作者：

Choi, Hyunsung ^{[1
]}

Chang, Hyun Joon ^{[1
]}

Shin, Yongwoo ^{[2
,3
]}

Kim, Jae In ^{[1
]}

Park, Harold S. ^{[2
]}

Yoon, Gwonchan ^{[1
,2
]}

Na, Sungsoo ^{[1
]}

机构：

[1] Korea Univ, Dept Mech Engn, Seoul 136701, South Korea

[2] Boston Univ, Dept Mech Engn, Boston, MA 02215 USA

[3] Boston Univ, Div Mat Sci & Engn, Boston, MA 02215 USA

来源：

RSC ADVANCES | 2015年 / 5卷 / 61期

关键词：

ELASTIC NETWORK MODELS; AMYLOID FIBRILS; PROTEIN; CONVERSION; DYNAMICS; MICROTUBULES; MOTIONS;

D O I：

10.1039/c5ra08015k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The HET-s prion fibril, which is found in the filamentous fungus Podospora anserina, exhibits conformational changes due to variations in pH. Here, we explain the effects of changing pH on the conformational changes of fibrils through the fundamental eigenmodes of the fibrils, in particular the torsional and bending modes, using a parameter free elastic network model. In particular, the motion resulting from these fundamental eigenmodes is found to be very similar to the conformational changes stimulated by pH variations as shown in previous experimental results. Finally, we calculated the mechanical properties

引用

页码：49263 / 49269

页数：7

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