Paraneoplastic optic neuropathy and cerebellar ataxia with small cell carcinoma of the lung

被引：24
作者：
Thambisetty, MR
Scherzer, CR
Yu, ZY
Lennon, VA
Newman, NJ
机构：
[1] Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
[2] Emory Univ, Sch Med, Dept Ophthalmol, Atlanta, GA 30322 USA
[3] Emory Univ, Sch Med, Dept Neurosurg, Atlanta, GA 30322 USA
[4] Mayo Clin & Mayo Fdn, Dept Immunol, Rochester, MN 55905 USA
[5] Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN 55905 USA
[6] Mayo Clin & Mayo Fdn, Dept Lab Med Pathol, Rochester, MN 55905 USA
来源：
JOURNAL OF NEURO-OPHTHALMOLOGY | 2001年 / 21卷 / 03期
关键词：
neuroimmunology; neuro-ophthalmology; oncology;
D O I：
10.1097/00041327-200109000-00002
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Bilateral optic neuropathy and subacute cerebellar ataxia were manifestations of a paraneoplastic neurologic disorder in a woman found to have small cell carcinoma of the lung. Serologic tests revealed a neuronal autoantibody specific for CRMP-5, a 62-kd member of the collapsin response-mediating protein family. Unexplained optic neuropathy in the setting of subacute cerebellar ataxia should cause suspicion of a paraneoplastic disorder and prompt testing for this autoantibody, especially in patients at risk for lung carcinoma.
引用
收藏
页码：164 / 167
页数：4
相关论文
共 15 条
[1]   PARA-NEOPLASTIC OPTIC NEURITIS AND ENCEPHALOMYELITIS - REPORT OF A CASE [J].
BOGHEN, D ;
SEBAG, M ;
MICHAUD, J .
ARCHIVES OF NEUROLOGY, 1988, 45 (03) :353-356
[2]   Paraneoplastic cerebellar syndrome and optic neuritis with anti-CV2 antibodies - Clinical response to excision of the primary tumor [J].
de la Sayette, V ;
Bertran, F ;
Honnorat, J ;
Schaeffer, S ;
Iglesias, S ;
Defer, G .
ARCHIVES OF NEUROLOGY, 1998, 55 (03) :405-408
[3]   Neuronal autoantibody titers in the course of small-cell lung carcinoma and platinum-associated neuropathy [J].
Galanis, E ;
Frytak, S ;
Rowland, KM ;
Sloan, JA ;
Lennon, VA .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 1999, 48 (2-3) :85-90
[4]  
Gazdar AF, 1981, SMALL CELL LUNG CANC, P145
[5]   Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes [J].
Honnorat, J ;
Byk, T ;
Kusters, I ;
Aguera, M ;
Ricard, D ;
Rogemond, V ;
Quach, T ;
Aunis, D ;
Sobel, A ;
Mattei, MG ;
Kolattukudy, P ;
Belin, MF ;
Antoine, JC .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (12) :4226-4232
[6]   Isolation and characterization of a bovine neural specific protein (CRMP-2) cDNA homologous to unc-33, a C-elegans gene implicated in axonal outgrowth and guidance [J].
Kamata, T ;
Subleski, M ;
Hara, Y ;
Yuhki, N ;
Kung, HF ;
Copeland, NG ;
Jenkins, NA ;
Yoshimura, T ;
Modi, W ;
Copeland, TD .
MOLECULAR BRAIN RESEARCH, 1998, 54 (02) :219-236
[7]  
Keltner JL, 1998, AM J OPHTHALMOL, V126, P296
[8]  
LENNON VA, 1996, TXB AUTOANTIBODIES, P139
[9]  
Luiz JE, 1998, J NEURO-OPHTHALMOL, V18, P178
[10]  
MALIK S, 1992, J CLIN NEURO-OPHTHAL, V12, P137
12