Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases

被引：287

作者：

Bartels, Tim ^{[1
]}

De Schepper, Sebastiaan ^{[1
]}

Hong, Soyon ^{[1
]}

机构：

[1] UCL, UK Dementia Res Inst, Inst Neurol, London WC1E 6BT, England

来源：

SCIENCE | 2020年 / 370卷 / 6512期

基金：

英国医学研究理事会;

关键词：

ALPHA-SYNUCLEIN; NEURAL CIRCUITS; A-BETA; BRAIN; TREM2; GLUCOCEREBROSIDASE; MODELS; FORM; TAU;

D O I：

10.1126/science.abb8587

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dementia is a rapidly rising global health crisis that silently disables families and ends lives and livelihoods around the world. To date, however, no early biomarkers or effective therapies exist. It is now clear that brain microglia are more than mere bystanders or amyloid phagocytes; they can act as governors of neuronal function and homeostasis in the adult brain. Here, we highlight the fundamental role of microglia as tissue-resident macrophages in neuronal health. Then, we suggest how chronic impairment in microglia-neuron cross-talk may secure the permanence of the failure of synaptic and neuronal function and health in Alzheimer's and Parkinson's diseases. Understanding how to assess and modulate microglia-neuron interactions critical for brain health will be key to developing effective therapies for dementia.

引用

页码：66 / +

页数：4

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