Mitofusin 2 Builds a Bridge between ER and Mitochondria

被引：114
|
作者：
Merkwirth, Carsten [1 ,2 ]
Langer, Thomas [1 ,2 ]
机构：
[1] Univ Cologne, Inst Genet, Ctr Mol Med CMMC, D-50674 Cologne, Germany
[2] Univ Cologne, Inst Genet, Cologne Excellence Cluster Cellular Stress Respon, D-50674 Cologne, Germany
来源：
CELL | 2008年 / 135卷 / 07期
关键词：
D O I：
10.1016/j.cell.2008.12.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mutations in mitofusin 2 (MFN2), a dynamin-like GTPase required for mitochondrial fusion, cause the peripheral neuropathy Charcot-Marie-Tooth type 2A. In a recent report in Nature, de Brito and Scorrano (2008) demonstrate a new function of MFN2-tethering the endoplasmic reticulum and mitochondria to control the efficiency of mitochondrial uptake of Ca(2+) ions.
引用
收藏
页码：1165 / 1167
页数：4
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