Mitofusin 2 Builds a Bridge between ER and Mitochondria

被引：114
|
作者：
Merkwirth, Carsten [1 ,2 ]
Langer, Thomas [1 ,2 ]
机构：
[1] Univ Cologne, Inst Genet, Ctr Mol Med CMMC, D-50674 Cologne, Germany
[2] Univ Cologne, Inst Genet, Cologne Excellence Cluster Cellular Stress Respon, D-50674 Cologne, Germany
来源：
CELL | 2008年 / 135卷 / 07期
关键词：
D O I：
10.1016/j.cell.2008.12.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mutations in mitofusin 2 (MFN2), a dynamin-like GTPase required for mitochondrial fusion, cause the peripheral neuropathy Charcot-Marie-Tooth type 2A. In a recent report in Nature, de Brito and Scorrano (2008) demonstrate a new function of MFN2-tethering the endoplasmic reticulum and mitochondria to control the efficiency of mitochondrial uptake of Ca(2+) ions.
引用
收藏
页码：1165 / 1167
页数：4
相关论文
共 50 条
  • [21] Mitofusin-mediated contacts between mitochondria and peroxisomes regulate mitochondrial fusion
    Alsayyah, Cynthia
    Singh, Manish K.
    Morcillo-Parra, Maria Angeles
    Cavellini, Laetitia
    Shai, Nadav
    Schmitt, Christine
    Schuldiner, Maya
    Zalckvar, Einat
    Mallet, Adeline
    Belgareh-Touze, Naima
    Zimmer, Christophe
    Cohen, Mickael M.
    PLOS BIOLOGY, 2024, 22 (04)
  • [22] Highlighting the endoplasmic reticulum-mitochondria connection: Focus on Mitofusin 2
    Filadi, Riccardo
    Greotti, Elisa
    Pizzo, Paola
    PHARMACOLOGICAL RESEARCH, 2018, 128 : 42 - 51
  • [23] Mitofusin 2 controls calcium transmission between the SR and mitochondria and regulates the bioenergetic feedback response in cardiac myocytes
    Meiser, M.
    Kohlhaas, M.
    Chen, Y.
    Csordas, G.
    Dorn, G.
    Maack, C.
    CARDIOVASCULAR RESEARCH, 2012, 93 : S49 - S49
  • [24] A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver
    Sood, Aditi
    Jeyaraju, Danny Vijey
    Prudent, Julien
    Caron, Alexandre
    Lemieux, Philippe
    McBride, Heidi May
    Laplante, Mathieu
    Toth, Katalin
    Pellegrini, Luca
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (45) : 16017 - 16022
  • [25] Mitofusin 2 ablation increases endoplasmic reticulum-mitochondria coupling
    Filadi, Riccardo
    Greotti, Elisa
    Turacchio, Gabriele
    Luini, Alberto
    Pozzan, Tullio
    Pizzo, Paola
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (17) : E2174 - E2181
  • [26] VoIP builds a better bridge
    不详
    COMMUNICATIONS NEWS, 2000, 37 (12): : 20 - +
  • [27] CHINA BUILDS RECORD BRIDGE
    HU, CN
    CIVIL ENGINEERING, 1985, 55 (02): : 60 - 61
  • [28] Mitofusin 2: A mitochondria-shaping protein with signaling roles beyond fusion
    De Brito, Olga Martins
    Scorrano, Luca
    ANTIOXIDANTS & REDOX SIGNALING, 2008, 10 (03) : 621 - 633
  • [29] LOCAL Ca2+-ROS CROSS TALK BETWEEN ER AND MITOCHONDRIA
    Booth, David M.
    Varnai, Peter
    Hajnoczky, Gyorgy
    FREE RADICAL BIOLOGY AND MEDICINE, 2017, 112 : 10 - 10
  • [30] Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether
    Naon, Deborah
    Zaninello, Marta
    Giacomello, Marta
    Varanita, Tatiana
    Grespi, Francesca
    Lakshminaranayan, Sowmya
    Serafini, Annalisa
    Semenzato, Martina
    Herkenne, Stephanie
    Isabel Hernandez-Alvarez, Maria
    Zorzano, Antonio
    De Stefani, Diego
    Dorn, Gerald W., II
    Scorrano, Luca
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (40) : 11249 - 11254
12345