Mitofusin 2 Builds a Bridge between ER and Mitochondria

被引：114

作者：

Merkwirth, Carsten ^{[1
,2
]}

Langer, Thomas ^{[1
,2
]}

机构：

[1] Univ Cologne, Inst Genet, Ctr Mol Med CMMC, D-50674 Cologne, Germany

[2] Univ Cologne, Inst Genet, Cologne Excellence Cluster Cellular Stress Respon, D-50674 Cologne, Germany

来源：

CELL | 2008年 / 135卷 / 07期

关键词：

D O I：

10.1016/j.cell.2008.12.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mutations in mitofusin 2 (MFN2), a dynamin-like GTPase required for mitochondrial fusion, cause the peripheral neuropathy Charcot-Marie-Tooth type 2A. In a recent report in Nature, de Brito and Scorrano (2008) demonstrate a new function of MFN2-tethering the endoplasmic reticulum and mitochondria to control the efficiency of mitochondrial uptake of Ca(2+) ions.

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收藏

页码：1165 / 1167

页数：4

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