Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase

被引：1078
作者：
Nagy, L
Kao, HY
Chakravarti, D
Lin, RJ
Hassig, CA
Ayer, DE
Schreiber, SL
Evans, RM
机构：
[1] UNIV CALIF SAN DIEGO,SCH MED,GRAD PROGRAM MOL PATHOL,LA JOLLA,CA 92093
[2] HARVARD UNIV,HOWARD HUGHES MED INST,DEPT CHEM & BIOL CHEM,CAMBRIDGE,MA 02138
[3] UNIV UTAH,HUNTSMAN CANC INST,DEPT ONCOL SCI,SALT LAKE CITY,UT 84112
来源：
CELL | 1997年 / 89卷 / 03期
关键词：
THYROID-HORMONE RECEPTOR; AVIAN ERYTHROBLASTOSIS VIRUS; RETINOIC ACID; ERBB ONCOGENES; CO-REPRESSOR; V-ERBA; EXPRESSION; DIFFERENTIATION; ACTIVATION; INTERACTS;
D O I：
10.1016/S0092-8674(00)80218-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The transcriptional corepressors SMRT and N-CoR function as silencing mediators for retinoid and thyroid hormone receptors. Here we show that SMRT and N-CoR directly interact with mSin3A, a corepressor for the Mad-Max heterodimer and a homolog of the yeast global-transcriptional repressor Sin3p. In addition, we demonstrate that the recently characterized histone deacetylase 1 (HDAC1) interacts with Sin3A and SMRT to form a multisubunit repressor complex. Consistent with this model, we find that HDAC inhibitors synergize with retinoic acid to stimulate hormone-responsive genes and differentiation of myeloid leukemia (HL-60) cells. This work establishes a convergence of repression pathways for bHLH-Zip proteins and nuclear receptors and suggests this type of regulation may be more widely conserved than previously suspected.
引用
收藏
页码：373 / 380
页数：8
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