Chemistry and Biological Activities of 1,3-Thiazolidin-4-ones

被引:72
作者
Cunico, Wilson [1 ]
Gomes, Claudia R. B. [1 ]
Vellasco, Walcimar T., Jr. [1 ]
机构
[1] Inst Tecnol Farm Farmanguinhos Fiocruz, BR-21041250 Rio De Janeiro, Brazil
关键词
D O I
10.2174/157019308786242232
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
1,3-Thiazolidin-4-ones are an important group of heterocyclic compounds that are used in the field of medicinal chemistry. The utility of 1,3-thiazolidin-4-ones as synthons for various biological compounds has given impetus to these studies. In recent years, 1,3-thiazoldin-4-ones have been among the most extensively studied compounds. This review aims to review the work reported on the chemistry and biological activities of 1,3-thiazolidin-4-ones during the past few years.
引用
收藏
页码:336 / 344
页数:9
相关论文
共 48 条
[1]   Synthesis and anticonvulsant activity of some potential thiazolidinonyl 2-oxo/thiobarbituric acids [J].
Agarwal, A. ;
Lata, S. ;
Saxena, K. K. ;
Srivastava, V. K. ;
Kumar, A. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2006, 41 (10) :1223-1229
[2]   Synthesis of newer thiadiazolyl and thiazolidinonyl quinazolin-4(3H)-ones as potential anticonvulsant agents [J].
Archana ;
Srivastava, VK ;
Kumar, A .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2002, 37 (11) :873-882
[3]   Novel inhibitors of an emerging target in Mycobacterium tuberculosis;: Substituted thiazolidinones as inhibitors of dTDP-rhamnose synthesis [J].
Babaoglu, K ;
Page, MA ;
Jones, VC ;
McNeil, MR ;
Dong, CJ ;
Naismith, JH ;
Lee, RE .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (19) :3227-3230
[4]   Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents [J].
Barreca, ML ;
Balzarini, J ;
Chimirri, A ;
De Clercq, E ;
De Luca, L ;
Höltje, HD ;
Höltje, M ;
Monforte, AM ;
Monforte, P ;
Pannecouque, C ;
Rao, A ;
Zappalà, M .
JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (24) :5410-5413
[5]   Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents [J].
Barreca, ML ;
Chimirri, A ;
De Luca, L ;
Monforte, AM ;
Monforte, P ;
Rao, A ;
Zappalà, M ;
Balzarini, J ;
De Clercq, E ;
Pannecouque, C ;
Witvrouw, M .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (13) :1793-1796
[6]   Thiazolidin-4-one formation. Mechanistic and synthetic aspects of the reaction of imines and mercaptoacetic acid under microwave and conventional heating [J].
Bolognese, A ;
Correale, G ;
Manfra, M ;
Lavecchia, A ;
Novellino, E ;
Barone, V .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2004, 2 (19) :2809-2813
[7]   Microwave-assisted synthesis of 1,3-thiazolidin-4-ones and 2-aryl-1,3-oxathiolan-5-ones [J].
Cunico, Wilson ;
Vellasco Junior, Walcimar T. ;
Moreth, Marcele ;
Gomes, Claudia R. B. .
LETTERS IN ORGANIC CHEMISTRY, 2008, 5 (05) :349-352
[8]   One-pot synthesis of 2-isopropyl-3-benzyl-1,3-thiazolidin-4-ones and 2-phenyl-3-isobutyl-1,3-thiazolidin-4-ones from valine, arenealdehydes and mercaptoacetic acid [J].
Cunico, Wilson ;
Gorries, Claudia R. B. ;
Ferreira, Maria de Lourdes G. ;
Capri, Liliane R. ;
Soares, Marcio ;
Wardell, Solange M. S. V. .
TETRAHEDRON LETTERS, 2007, 48 (35) :6217-6220
[9]   One-pot synthesis of 1,3-thiazolidin-4-ones derivatives from 2-amino-1,3,4-thiadiazole [J].
Cunico, Wilson ;
Gornes, Claudia R. B. ;
Ferreira, Maria de Lourdes G. ;
Capri, Liliane R. ;
Santos, Margareth R. L. ;
Sa, Paula M. ;
Boechat, Nubia ;
Bastos, Monica M. ;
Maciel, Lindalva C. ;
Mayer, Lucia M. U. .
LETTERS IN ORGANIC CHEMISTRY, 2007, 4 (07) :505-508
[10]   Racemic 2-isopropyl-3-(2-nitrob-enzyl)-1,3-thiazolidin-4-one crystallizes in the space group P212121 with Z′=2:: two different interpenetrating three-dimensional frameworks formed by C-H•••O hydrogen bond [J].
Cunico, Wilson ;
Gomes, Claudia R. B. ;
Warden, Solange M. S. V. ;
Low, John N. ;
Glidewell, Christopher .
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 2007, 63 (07) :O411-O414