Lipid-Bilayer-Spanning DNA Nanopores with a Bifunctional Porphyrin Anchor

被引：170
作者：
Burns, Jonathan R. [1 ]
Goepfrich, Kerstin [2 ]
Wood, James W. [3 ]
Thacker, Vivek V. [2 ]
Stulz, Eugen [3 ]
Keyser, Ulrich F. [2 ]
Howorka, Stefan [1 ]
机构：
[1] UCL, Dept Chem, London WC1H 0AJ, England
[2] Univ Cambridge, Cavendish Lab, Cambridge CB3 0HE, England
[3] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 46期
基金：
英国工程与自然科学研究理事会;
关键词：
DNA structures; membranes; nanopores; porphyrins; single-molecule studies; ORIGAMI; MEMBRANE; CHANNELS; SHAPES; PORES;
D O I：
10.1002/anie.201305765
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Holding tight: An artificial membrane nanopore assembled from DNA oligonucleotides carries porphyrin tags (red), which anchor the nanostructure into the lipid bilayer. The porphyrin moieties also act as fluorescent dyes to aid the microscopic visualization of the DNA nanopore. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：12069 / 12072
页数：4
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