Conceptual barriers to understanding physical barriers

被引：50
作者：
Lingaraju, Amulya [1 ]
Long, Tiha M. [1 ]
Wang, Yitang [1 ]
Austi, Jotham R., II [2 ]
Turner, Jerrold R. [1 ]
机构：
[1] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
[2] Univ Chicago, Off Shared Res Facil, Adv Electron Microscopy Facil, Chicago, IL 60637 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2015年 / 42卷
关键词：
Tight junction; Lipid; Membrane microdomain; Barrier; Claudin; TIGHT-JUNCTION STRUCTURE; TRANSEPITHELIAL ELECTRICAL-RESISTANCE; ZONULA OCCLUDENS-1 AND-2; NONLAMELLAR LIPID PHASE; HEXAGONAL-II-PHASE; BASIC-AMINO-ACIDS; DIARRHEA IN-VIVO; EPITHELIAL-CELLS; MDCK-CELLS; PARACELLULAR PERMEABILITY;
D O I：
10.1016/j.semcdb.2015.04.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The members of the large family of claudin proteins regulate ion and water flux across the tight junction. Many claudins, e.g. claudins 2 and 15, accomplish this by forming size- and charge-selective paracellular channels. Claudins also appear to be essential for genesis of tight junction strands and recruitment of other proteins to these sites. What is less clear is whether claudins form the paracellular seal. While this seal is defective when claudins are disrupted, some results, including ultrastructural and biochemical data, suggest that lipid structures are an important component of tight junction strands and may be responsible for the paracellular seal. This review highlights current understanding of claudin contributions to barrier function and tight junction structure and suggests a model by which claudins and other tight junction proteins can drive assembly and stabilization of a lipid-based strand structure. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：13 / 21
页数：9
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