Body weight and waist circumference as predictors of vitamin D deficiency in patients with type 2 diabetes and cardiovascular disease

被引:11
作者
Kavaric, Sreten [1 ]
Vuksanovic, Milica [2 ]
Bozovic, Dragica [3 ]
Jovanovic, Marko [4 ]
Jeremic, Veljko [4 ]
Radojicic, Zoran [4 ]
Pekic, Sandra [5 ,6 ]
Popovic, Vera [5 ,6 ]
机构
[1] Clin Ctr Montenegro, Clin Internal Med, Podgorica, Montenegro
[2] PZU Dr Vuksanov, Bar, Montenegro
[3] Clin Ctr Montenegro, Dept Biochem Anal, Podgorica, Montenegro
[4] Univ Belgrade, Fac Org Sci, Belgrade, Serbia
[5] Univ Belgrade, Clin Ctr Serbia, Clin Endocrinol Diabet & Dis Metab, Belgrade, Serbia
[6] Univ Belgrade, Fac Med, Belgrade, Serbia
关键词
diabetes mellitus; type; 2; cardiovascular disease; vitamin d deficiency; body weight; body mass index; risk factors; IMPAIRED GLUCOSE-TOLERANCE; INSULIN-SECRETION; D INSUFFICIENCY; HIGH PREVALENCE; SERUM; 25-HYDROXYVITAMIN-D; 1,25-DIHYDROXYVITAMIN D-3; 25(OH)D CONCENTRATIONS; PARATHYROID-HORMONE; HEART-FAILURE; ELDERLY-MEN;
D O I
10.2298/VSP110713035K
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background/Aim. Vitamin D deficiency is a well-established risk factor for bone disease, but emerging data suggest that altered vitamin D homeostasis may play a role in the development of type 2 diabetes mellitus (T2DM), dyslipidemia hypertension, and other cardiovascular diseases (CVD). The aim of this study was to investigate the prevalence of vitamin D deficiency in patients with T2DM with/without CVD, to correlate it with anthropometric and metabolic parameters and to determine the predictors of vitamin D deficiency. Methods. A total of 88 patients with T2DM (49 male/39 female, aged 61.0 +/- 0.9 yrs, body mass index (BMI) 29.9 +/- 0.4 kg/m(2)) and 67 patients (44 male/23 female, aged 63.6 +/- 1.0 yrs, BMI 29.2 +/- 0.5 kg/m(2)) with T2DM and CVD (myocardial infarction in 57 patients and angina pectoris in 10 patients) were included in this study. These patients were compared with 87 healthy subjects (35 male/52 female, aged 52.8 +/- 1.4 yrs, BMI 27.2 +/- 0.5 kg/m(2)). Weight, height, waist circumference and BMI were recorded in all patients. Also, total cholesterol, triglycerides, hemoglobin A1c (HbA(1c)) and 25-hydroxy-vitamin D [25(OH)D] levels were measured in all. According to 25(OH)D level, all subjects were divided into three categories: severe vitamin D deficiency (5 <= 15 ng/mL), vitamin D insufficiency (15-20 ng/mL) and vitamin D sufficiency ((sic)20 ng/mL). We correlated vitamin D levels with anthropometric and metabolic status and determined the predictors of vitamin D deficiency. Results. Severe vitamin D deficiency was registered in 16.1% healthy subjects, in 21.6% patients with T2DM and in 26.9% patients with T2DM and CVD. Patients with T2DM who were vitamin D deficient had increased weight, waist circumference, cholesterol and triglyceride levels when compared with patients with T2DM who had sufficient vitamin D level. 25(OH)D levels correlated with BMI and waist circumference in all subjects, but did not correlate with metabolic parameters (lipids, HbA(1c)). The best predictors of vitamin D level in all subjects were weight, waist circumference and BMI. Conclusion. The high prevalence of vitamin D deficiency in patients with T2DM and particularly in patients with T2DM and CVD suggests that supplementation with vitamin D may be beneficial although there is still not sufficient evidence for recommending prescribing vitamin D.
引用
收藏
页码:163 / 169
页数:7
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