Not too much and not too little

被引:1
作者
van Helden, Paul [1 ]
机构
[1] Univ Stellenbosch, Dept Biomed Sci, Fac Hlth Sci, Cape Town, South Africa
关键词
D O I
10.1038/embor.2012.153
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We tend to think in black and white terms of good versus bad alleles and their meaning for disease. However, in doing so, we ignore the potential importance of heterozygous alleles.
引用
收藏
页码:942 / 942
页数:1
相关论文
共 3 条
[1]   Association analysis of the LTA4H gene polymorphisms and pulmonary tuberculosis in 9115 subjects [J].
Curtis, James ;
Kopanitsa, Liliya ;
Stebbings, Emma ;
Speirs, Arran ;
Ignatyeva, Olga ;
Balabanova, Yanina ;
Nikolayevskyy, Vladyslav ;
Hoffner, Sven ;
Horstmann, Rolf ;
Drobniewski, Francis ;
Nejentsev, Sergey .
TUBERCULOSIS, 2011, 91 (01) :22-25
[2]   Correlation between fitness and genetic diversity [J].
Reed, DH ;
Frankham, R .
CONSERVATION BIOLOGY, 2003, 17 (01) :230-237
[3]   The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans [J].
Tobin, David M. ;
Vary, Jay C., Jr. ;
Ray, John P. ;
Walsh, Gregory S. ;
Dunstan, Sarah J. ;
Bang, Nguyen D. ;
Hagge, Deanna A. ;
Khadge, Saraswoti ;
King, Mary-Claire ;
Hawn, Thomas R. ;
Moens, Cecilia B. ;
Ramakrishnan, Lalita .
CELL, 2010, 140 (05) :717-730