Tight junctions: Molecular architecture and function

被引：237

作者：

Aijaz, S ^{[1
]}

Balda, MS ^{[1
]}

Matter, K ^{[1
]}

机构：

[1] UCL, Inst Ophthalmol, Div Cell Biol, London, England

来源：

INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 248 | 2006年 / 248卷

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

intercellular junctions; tight junctions; adhesion; differentiation; cell polarity; signal transduction; oncogenesis; permeability;

D O I：

10.1016/S0074-7696(06)48005-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tight junctions are the most apical component of the epithelial junctional complex and are crucial for the formation and functioning of epithelial and endothelial barriers. They regulate selective diffusion of ions and solutes along the paracellular pathway and restrict apical/basolateral intramembrane diffusion of lipids. Research over the past years provided much insight into the molecular composition of tight junctions, and we are starting to understand the mechanisms that permit selective paracellular diffusion, Moreover, a complex network of proteins has been identified at tight junctions that is based on cytoskeleton-linked adaptors that recruit and thereby often regulate different types of signaling components that regulate epithelial proliferation, differentiation, and polarization.

引用

页码：261 / 298

页数：38

共 247 条

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[2] Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition [J].