Synthesis and evaluation of novel diphenylthiazole derivatives as potential anti-inflammatory agents

被引：9
|
作者：
Abdelazeem, Ahmed H. [1 ]
Habash, Maha [2 ]
Maghrabi, Ibrahim A. [3 ]
Taha, Mutasem O. [4 ]
机构：
[1] Beni Suef Univ, Fac Pharm, Dept Med Chem, Bani Suwayf 62514, Egypt
[2] Appl Sci Univ, Fac Pharm, Dept Pharmacognosy, Amman, Jordan
[3] Taif Univ, Dept Clin Pharm, Coll Pharm, At Taif 21974, Saudi Arabia
[4] Univ Jordan, Fac Pharm, Dept Pharmaceut Sci, Drug Discovery Unit, Amman, Jordan
来源：
MEDICINAL CHEMISTRY RESEARCH | 2015年 / 24卷 / 10期
关键词：
Diphenylthiazole; Anti-inflammatory; Docking; Inflamed animal paws; PAW EDEMA; DOCKING; DESIGN;
D O I：
10.1007/s00044-015-1418-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In the presented study, we synthesized a novel series of 18 diphenylthiazole derivatives and tested their anti-inflammatory properties. They showed significant anti-inflammatory properties in inflamed mice paws animal model. Docking-based analysis suggested that they act as COX enzyme inhibitors. The most potent compound 9e is significantly more active in reducing inflamed animal paws compared to diclofenac. Accordingly, we believe these compounds are good leads for further development into potent anti-inflammatory drugs.
引用
收藏
页码：3681 / 3695
页数：15
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