Colostrum from cows immunized with a veterinary vaccine against bovine rotavirus displays enhanced in vitro anti-human rotavirus activity

被引:15
作者
Civra, Andrea [1 ]
Altomare, Alessandra [2 ]
Francese, Rachele [1 ]
Donalisio, Manuela [1 ]
Aldini, Giancarlo [2 ]
Lembo, David [1 ]
机构
[1] Univ Turin, Dept Clin & Biol Sci, I-10043 Orbassano, Italy
[2] Univ Milan, Dept Pharmaceut Sci, I-20133 Milan, Italy
关键词
rotavirus; colostrum; cows; hyperimmune; immunoglobulins; CHILDREN LESS-THAN-5 YEARS; PASSIVE-IMMUNIZATION; CLINICAL MEDICINE; GROWTH-FACTORS; ANTIBODIES; MILK; DIARRHEA; IMMUNOGLOBULIN; PROTEINS; COMPONENTS;
D O I
10.3168/jds.2018-16016
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Human rotaviruses represent a major cause of severe diarrheal disease in infants and young children. The limited impact of oral vaccines on global estimates of rotavirus mortality and the suboptimal use of oral rehydration justify the need for alternative prophylactic and therapeutic strategies, especially for immunocompromised hosts. The protective effects of colostrum-the first milk produced during the initial 24 to 48 h after parturition-are well documented in the literature. In particular, the ingestion of hyperimmune bovine colostrum has been proposed as an alternative preventive approach against human rotavirus gastroenteritis. Although the immunization of pregnant cows with human rotavirus boosts the release of specific immunoglobulin G in bovine colostrum, it raises regulatory and safety issues. In this study, we demonstrated that the conventional bovine rotavirus vaccine is sufficient to enhance the anti-human rotavirus protective efficacy of bovine colostrum, thus providing a conservative approach to produce hyperimmune bovine colostrum, making it exploitable as a functional food.
引用
收藏
页码:4857 / 4869
页数:13
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