Tumors sound the alarmin(s)

被引：72
作者：
Coffelt, Seth B. [1 ]
Scandurro, Aline B. [1 ]
机构：
[1] Tulane Univ, Dept Microbiol & Immunol, New Orleans, LA 70118 USA
来源：
CANCER RESEARCH | 2008年 / 68卷 / 16期
关键词：
D O I：
10.1158/0008-5472.CAN-08-0044
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent evidence suggests that inflammatory molecules play critical roles in the development and progression of numerous tumors. However, one specific group of inflammatory molecules whose importance has been established in host immune responses, termed alarmins, has been largely overlooked in cancer biology. The function of several alarmins-including the defensins, LL-37, and HMGB1-in tumor development, progression, or suppression is discussed here. Taken together, these studies indicate that alarmins represent potential new targets for manipulation in a variety of tumors.
引用
收藏
页码：6482 / 6485
页数：4
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