Instrumental characterization of the smectite clay-gentamicin hybrids

被引：26

作者：

Rapacz-Kmita, Alicja ^{[1
]}

Stodolak-Zych, Ewa ^{[1
]}

Ziabka, Magdalena ^{[1
]}

Rozycka, Agnieszka ^{[1
]}

Dudek, Magdalena ^{[2
]}

机构：

[1] AGH Univ Sci & Technol, Fac Mat Sci & Ceram, PL-30059 Krakow, Poland

[2] AGH Univ Sci & Technol, Fac Energy & Fuels, PL-30059 Krakow, Poland

来源：

BULLETIN OF MATERIALS SCIENCE | 2015年 / 38卷 / 04期

关键词：

Clay mineral; drug carrier; intercalation; XRD; FTIR; IN-VITRO RELEASE; DRUG-RELEASE; MONTMORILLONITE; INTERCALATION; DELIVERY; NANOCOMPOSITES; COMPOSITES; SYSTEMS; WATER;

D O I：

10.1007/s12034-015-0943-7

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

This paper focusses on the intercalation of clay mineral with gentamicin (an aminoglycoside antibiotic). The smectite clay-gentamicin hybrids were prepared by a solution intercalation at 60(a similar to)C and the process was carried out on unmodified smectite clay and on smectite after Na+ ionic activation. The resulting structural/microstructural properties and the potential for introducing gentamicin between smectite clay layers were investigated by means of X-ray diffraction, Fourier transform infrared spectroscopic techniques and transmission electron microscopy and scanning electron microscopy with energy-dispersive spectroscopy X-ray analysis. The results confirm the successful intercalation of gentamicin into the interlayer space of smectite clay, demonstrating that the material thus obtained could potentially be used as a drug carrier.

引用

页码：1069 / 1078

页数：10

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