Instrumental characterization of the smectite clay-gentamicin hybrids

被引：26

作者：

Rapacz-Kmita, Alicja ^{[1
]}

Stodolak-Zych, Ewa ^{[1
]}

Ziabka, Magdalena ^{[1
]}

Rozycka, Agnieszka ^{[1
]}

Dudek, Magdalena ^{[2
]}

机构：

[1] AGH Univ Sci & Technol, Fac Mat Sci & Ceram, PL-30059 Krakow, Poland

[2] AGH Univ Sci & Technol, Fac Energy & Fuels, PL-30059 Krakow, Poland

来源：

BULLETIN OF MATERIALS SCIENCE | 2015年 / 38卷 / 04期

关键词：

Clay mineral; drug carrier; intercalation; XRD; FTIR; IN-VITRO RELEASE; DRUG-RELEASE; MONTMORILLONITE; INTERCALATION; DELIVERY; NANOCOMPOSITES; COMPOSITES; SYSTEMS; WATER;

D O I：

10.1007/s12034-015-0943-7

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

This paper focusses on the intercalation of clay mineral with gentamicin (an aminoglycoside antibiotic). The smectite clay-gentamicin hybrids were prepared by a solution intercalation at 60(a similar to)C and the process was carried out on unmodified smectite clay and on smectite after Na+ ionic activation. The resulting structural/microstructural properties and the potential for introducing gentamicin between smectite clay layers were investigated by means of X-ray diffraction, Fourier transform infrared spectroscopic techniques and transmission electron microscopy and scanning electron microscopy with energy-dispersive spectroscopy X-ray analysis. The results confirm the successful intercalation of gentamicin into the interlayer space of smectite clay, demonstrating that the material thus obtained could potentially be used as a drug carrier.

引用

页码：1069 / 1078

页数：10

共 38 条

[1] Use of clays as drug delivery systems: Possibilities and limitations [J].

Aguzzi, C. ;

Cerezo, P. ;

Viseras, C. ;

Caramella, C. .

APPLIED CLAY SCIENCE, 2007, 36 (1-3) :22-36

[2] Molecular Hydraulic Properties of Montmorillonite: A Polarized Fourier Transform Infrared Spectroscopic Study [J].

Amarasinghe, Priyanthi M. ;

Katti, Kalpana S. ;

Katti, Dinesh R. .

APPLIED SPECTROSCOPY, 2008, 62 (12) :1303-1313

[3] Nature of organic fluid-montmorillonite interactions: An FTIR spectroscopic study [J].

Amarasinghe, Priyanthi M. ;

Katti, Kalpana S. ;

Katti, Dinesh R. .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2009, 337 (01) :97-105

[4] In situ mineralized hydroxyapatite on amino acid modified nanoclays as novel bone biomaterials [J].

Ambre, Avinash ;

Katti, Kalpana S. ;

Katti, Dinesh R. .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2011, 31 (05) :1017-1029

[5]

[Anonymous], HDB PHARM EXCIPIENTS

[6]

Baia M., 2008, RAMAN SERS INVESTIGA

[7]

BAILEY SW, 1988, REV MINERAL, V19, P189

[8] Biopolymer-clay nanocomposites based on chitosan intercalated in montmorillonite [J].

Darder, M ;

Colilla, M ;

Ruiz-Hitzky, E .

CHEMISTRY OF MATERIALS, 2003, 15 (20) :3774-3780

[9] Therapeutic applications of implantable drug delivery systems [J].

Dash, AK ;

Cudworth, GC .

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 1998, 40 (01) :1-12

[10] The systems containing clays and clay minerals from modified drug release: A review [J].

de Sousa Rodrigues, Luis Alberto ;

Figueiras, Ana ;

Veiga, Francisco ;

de Freitas, Rivelilson Mendes ;

Cunha Nunes, Livio Cesar ;

da Silva Filho, Edson Cavalcanti ;

da Silva Leite, Cleide Maria .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2013, 103 :642-651

← 1 2 3 4 →