Ailanthoidol Derivatives and their Anti-inflammatory Effects

被引：9

作者：

Lee, Na Li ^{[1
,2
]}

Lee, Jae Jun ^{[1
,2
]}

Kim, Jin-Kyung ^{[3
]}

Jun, Jong-Gab ^{[1
,2
]}

机构：

[1] Hallym Univ, Dept Chem, Chunchon 200702, South Korea

[2] Hallym Univ, Inst Nat Med, Chunchon 200702, South Korea

[3] Catholic Univ Daegu, Coll Nat Sci, Dept Biomed Sci, Gyeungsan Si 700702, South Korea

来源：

BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2012年 / 33卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Ailanthoidol; 2-Arylbenzo[b]furan; Anti-inflammatory; Nitric oxide; Iodine-induced cyclization; LIGNANS;

D O I：

10.5012/bkcs.2012.33.6.1907

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ailanthoidol showed a strong anti-inflammatory effect in a previous result. Ailanthoidol derivatives were prepared for the anti-inflammatory test using Sonogashira coupling, iodine induced cyclization and Wittig reaction. Anti-inflammatory effects of the prepared ailanthoidol derivatives were examined in lipopolysaccharide (LPS)-stimulated RAW 264-7 macrophages. The results showed that some ailanthoidol derivatives inhibited significantly the production of inflammatory mediator nitric oxide.

引用

页码：1907 / 1912

页数：6

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