Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities

被引：33

作者：

Eroglu, Zeynep ^{[1
]}

Holmen, Sheri L. ^{[2
]}

Chen, Qing ^{[3
]}

Khushalani, Nikhil I. ^{[1
]}

Amaravadi, Ravi ^{[4
]}

Thomas, Reena ^{[5
]}

Ahmed, Kamran A. ^{[1
]}

Tawbi, Hussein ^{[6
]}

Chandra, Sunandana ^{[7
]}

Markowitz, Joseph ^{[1
]}

Smalley, Inna ^{[1
]}

Liu, James K. C. ^{[1
]}

Chen, Yian Ann ^{[1
]}

Najjar, Yana G. ^{[8
]}

Karreth, Florian A. ^{[1
]}

Abate-Daga, Daniel ^{[1
]}

Glitza, Isabella C. ^{[6
]}

Sosman, Jeffrey A. ^{[7
]}

Sondak, Vernon K. ^{[1
]}

Bosenberg, Marcus ^{[9
]}

Herlyn, Meenhard ^{[3
]}

Atkins, Michael B. ^{[6
,10
]}

Kluger, Harriet ^{[9
]}

Margolin, Kim ^{[11
]}

Forsyth, Peter A. ^{[1
]}

Davies, Michael A. ^{[6
]}

Smalley, Keiran S. M. ^{[1
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA

[2] Univ Utah, Hlth Sci Ctr, Salt Lake City, UT USA

[3] Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA

[4] Univ Penn, Philadelphia, PA 19104 USA

[5] Stanford Univ, Palo Alto, CA 94304 USA

[6] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[7] Northwestern Univ, Chicago, IL 60611 USA

[8] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA

[9] Yale Univ, New Haven, CT USA

[10] Georgetown Univ, Canc Ctr, Washington, DC USA

[11] City Hope Natl Med Ctr, Duarte, CA USA

来源：

PIGMENT CELL & MELANOMA RESEARCH | 2019年 / 32卷 / 03期

关键词：

brain metastases; immunotherapy; melanoma; metastasis; targeted therapy; BRAF INHIBITOR RESISTANCE; CELL LUNG-CANCER; OPEN-LABEL; ANTITUMOR-ACTIVITY; PLUS TRAMETINIB; PI3K PATHWAY; DABRAFENIB; SURVIVAL; TUMORS; MULTICENTER;

D O I：

10.1111/pcmr.12771

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System (CNS) Metastases in Tampa, Florida. In this white paper, we outline the current status of basic science, translational, and clinical research into melanoma brain metastasis development and therapeutic management. We further outline the important challenges that remain for the field and the critical barriers that need to be overcome for continued progress to be made in this clinically difficult area.

引用

页码：458 / 469

页数：12

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