Effect of steroids and the estrous cycle on uterine neuromedin U receptor expression

被引：12

作者：

Nandha, KA ^{[1
]}

Benito-Orfila, MA ^{[1
]}

Jamal, H ^{[1
]}

Akinsanya, KO ^{[1
]}

Bloom, SR ^{[1
]}

Smith, DM ^{[1
]}

机构：

[1] Hammersmith Hosp, Imperial Coll Sch Med, ICSM Endocrine Unit, London W12 0NN, England

来源：

PEPTIDES | 1999年 / 20卷 / 10期

关键词：

neuromedin U; receptor expression; uterus; estrous cycle; ovariectomy; estrogen; progesterone; RU; 486;

D O I：

10.1016/S0196-9781(99)00124-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the role of estrogen and progesterone on rat uterine NmU receptor expression in both intact and ovariectomized animals and examined receptor expression through the estrous cycle. Chronic administration of beta-estradiol 3-benzoate (E-2) or progesterone in intact animals was devoid of any effect. RU486 caused a 2-fold up-regulation in NmU receptor density. Ovariectomy caused a 60% decrease in receptor density, but chronic E-2 administration to ovariectomized rats significantly increased NmU receptor density. The estrous cycle had no significant effect on NmU receptor density. These results suggest that NmU receptor expression is estrogen-dependent, whereas progesterone or a progestin-induced factor is involved in the modulation of this expression. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：1203 / 1209

页数：7

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