Phosphoinositide 3-kinases in cell migration

被引：199
作者：
Cain, Robert J. [1 ]
Ridley, Anne J. [1 ]
机构：
[1] Kings Coll London, Sch Biomed & Hlth Sci, Randall Div Cell & Mol Biophys, London SE1 1UL, England
来源：
BIOLOGY OF THE CELL | 2009年 / 101卷 / 01期
关键词：
actin cytoskeleton; cell migration; phosphoinositide; phosphoinositide 3-kinase (PI3K); Rho GTPase; signalling; BREAST-CANCER CELLS; NF-KAPPA-B; PHOSPHATIDYLINOSITOL; 3-KINASE; RHO-GTPASES; CADHERIN ADHESION; DISTINCT ROLES; TRANSENDOTHELIAL MIGRATION; DIFFERENTIAL REGULATION; INTEGRIN ACTIVATION; EMBRYONIC LETHALITY;
D O I：
10.1042/BC20080079
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cell migration is essential for many biological processes in animals and is a complex highly co-ordinated process that involves cell polarization, actin-driven protrusion and formation and turnover of cell adhesions. The PI3K (phosphoinositide 3-kinase) family of lipid kinases regulate cell migration in many different cell types, both through direct binding of proteins to their lipid products and indirectly through crosstalk with other pathways, such as Rho GTPase signalling. Emerging evidence suggests that the involvement of PI3Ks at different stages of migration varies even within one cell type, and is dependent on the combination of external stimuli, as well as on the signalling status of the cell. In addition, it appears that different PI3K isoforms have distinct roles in cell polarization and migration. This review describes how PI3K signalling is regulated by pro-migratory stimuli, and the diverse ways in which PI3K-mediated signal transduction contributes to different aspects of cell migration.
引用
收藏
页码：13 / 29
页数：17
相关论文
共 166 条
[1]   Essential role for the p110δ phosphoinositide 3-kinase in the allergic response [J].
Ali, K ;
Bilancio, A ;
Thomas, M ;
Pearce, W ;
Gilfillan, AM ;
Tkaczyk, C ;
Kuehn, N ;
Gray, A ;
Giddings, J ;
Peskett, E ;
Fox, R ;
Bruce, I ;
Walker, C ;
Sawyer, C ;
Okkenhaug, K ;
Finan, P ;
Vanhaesebroeck, B .
NATURE, 2004, 431 (7011) :1007-1011
[2]   Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFκB [J].
Amin, MA ;
Haas, CS ;
Zhu, K ;
Mansfield, PJ ;
Kim, MJ ;
Lackowski, NP ;
Koch, AE .
BLOOD, 2006, 107 (06) :2252-2261
[3]   CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes [J].
Andrade, Rosa M. ;
Wessendarp, Matthew ;
Gubbels, Marc-Jan ;
Striepen, Boris ;
Subauste, Carlos S. .
JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (09) :2366-2377
[4]   The regulation and function of Class III PI3Ks: novel roles for Vps34 [J].
Backer, Jonathan M. .
BIOCHEMICAL JOURNAL, 2008, 410 (01) :1-17
[5]   Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes [J].
Barreiro, O ;
Yáñez-Mó, M ;
Serrador, JM ;
Montoya, MC ;
Vicente-Manzanares, M ;
Tejedor, R ;
Furthmayr, H ;
Sánchez-Madrid, F .
JOURNAL OF CELL BIOLOGY, 2002, 157 (07) :1233-1245
[6]   Lim kinases, regulators of actin dynamics [J].
Bernard, Ora .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2007, 39 (06) :1071-1076
[7]   GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila [J].
Bernards, A .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2003, 1603 (02) :47-82
[8]   Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110α subunit of phosphoinositide 3-kinase [J].
Bi, L ;
Okabe, I ;
Bernard, DJ ;
Wynshaw-Boris, A ;
Nussbaum, RL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (16) :10963-10968
[9]   Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase [J].
Bi, L ;
Okabe, I ;
Bernard, DJ ;
Nussbaum, RL .
MAMMALIAN GENOME, 2002, 13 (03) :169-172
[10]   Key role of the p110δ isoforrn of PI3K in B-cell antigen and IL-4 receptor signaling:: comparative analysis of genetic and pharmacologic interference with p110δ function in B cells [J].
Bilancio, A ;
Okkenhaug, K ;
Camps, M ;
Emery, JL ;
Ruckle, T ;
Rommel, C ;
Vanhaesebroeck, B .
BLOOD, 2006, 107 (02) :642-650
12345678910