Exploring the Effect of Amphiphilic Polymer Architecture: Synthesis, Characterization, and Self-Assembly of Both Cyclic and Linear Poly(ethylene gylcol)-b-polycaprolactone

被引：107

作者：

Zhang, Boyu ^{[1
]}

Zhang, Hong ^{[1
]}

Li, Yejia ^{[1
]}

Hoskins, Jessica N. ^{[1
]}

Grayson, Scott M. ^{[1
]}

机构：

[1] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA

来源：

ACS MACRO LETTERS | 2013年 / 2卷 / 10期

基金：

美国国家科学基金会;

关键词：

BLOCK-COPOLYMERS; RADICAL POLYMERIZATION; CREMOPHOR-FREE; GENEXOL-PM; DIBLOCK; COMBINATION; CYCLIZATION; PACLITAXEL; MICELLES; VESICLES;

D O I：

10.1021/mz4003936

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

While amphiphilic block copolymers have demonstrated their utility for a range of practical applications, the behavior of cyclic block copolymers remains largely unexplored due to limited synthetic access. To investigate their micelle formation, biocompatible cyclic amphiphilic poly(ethylene glycol)-polycaprolactone, c-(PEG-PCL), was synthesized by a combination of ring-opening polymerization (ROP) and click chemistry. In addition, exactly analogous linear block copolymers have been prepared as a control sample to elucidate the role of polymer architecture in their self-assembly and acid-catalyzed degradation.

引用

收藏

页码：845 / 848

页数：4

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