Molecular insights into transgenerational non-genetic inheritance of acquired behaviours

被引：217
作者：
Bohacek, Johannes
Mansuy, Isabelle M. [1 ]
机构：
[1] Univ Zurich, Lab Neuroepigenet, CH-8057 Zurich, Switzerland
来源：
NATURE REVIEWS GENETICS | 2015年 / 16卷 / 11期
基金：
瑞士国家科学基金会;
关键词：
EPIGENETIC INHERITANCE; PRENATAL EXPOSURE; DNA METHYLATION; GLUCOCORTICOID-RECEPTOR; GENE-EXPRESSION; NONCODING RNAS; DUTCH FAMINE; SPERM; STRESS; CHROMATIN;
D O I：
10.1038/nrg3964
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Behavioural traits in mammals are influenced by environmental factors, which can interact with the genome and modulate its activity by complex molecular interplay. Environmental experiences can modify social, emotional and cognitive behaviours during an individual's lifetime, and result in acquired behavioural traits that can be transmitted to subsequent generations. This Review discusses the concept of, and experimental support for, non-genetic transgenerational inheritance of acquired traits involving the germ line in mammals. Possible mechanisms of induction and maintenance during development and adulthood are considered along with an interpretation of recent findings showing the involvement of epigenetic modifications and non-coding RNAs in male germ cells.
引用
收藏
页码：641 / 652
页数：12
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