Optimal long-term antithrombotic management of atrial fibrillation: life cycle management

被引：7

作者：

Pisters, R. ^{[1
]}

Elvan, A. ^{[2
]}

Crijns, H. J. G. M. ^{[3
]}

Hemels, M. E. W. ^{[1
,4
]}

机构：

[1] Rijnstate Arnhem, Dept Cardiol, Arnhem, Netherlands

[2] Isala Hosp Zwolle, Dept Cardiol, Zwolle, Netherlands

[3] Maastricht Univ, Med Ctr, Dept Cardiol, Maastricht, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr Nijmegen, Dept Cardiol, Nijmegen, Netherlands

来源：

NETHERLANDS HEART JOURNAL | 2018年 / 26卷 / 06期

关键词：

Atrial fibrillation; Anticoagulation; Stroke risk; Bleeding risk; NOAC; VKA; BLEEDING RISK; ORAL ANTICOAGULATION; STROKE PREVENTION; ELDERLY-PATIENTS; INTRACEREBRAL HEMORRHAGE; WARFARIN THERAPY; ADVANCED AGE; APIXABAN; IMPACT; ASPIRIN;

D O I：

10.1007/s12471-018-1118-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Optimal antithrombotic management of atrial fibrillation equals balancing between prevention of arterial thromboembolism, predominantly ischaemic stroke, and haemorrhagic complications. Over time different antithrombotic agents and strategies have been developed. At present, non-vitamin K antagonist oral anticoagulants (NOACs) are the first-line therapy for stroke prevention in patients with non-valvular atrial fibrillation (i.e. without a mechanical valve prosthesis or rheumatic heart disease). Considering the impact of the suboptimal adoption of recommended oral anticoagulant therapy, as experienced with the previous first-line vitamin K antagonists, this review focuses on adequate use of NOACs. As such, we address the most important and clinically challenging issues in the antithrombotic life cycle management for long-term stroke prevention in atrial fibrillation.

引用

页码：311 / 320

页数：10

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