Extension of DNA in a Nanochannel as a Rod-to-Coil Transition

被引：86

作者：

Tree, Douglas R. ^{[1
]}

Wang, Yanwei ^{[2
]}

Dorfman, Kevin D. ^{[1
]}

机构：

[1] Univ Minnesota Twin Cities, Dept Chem Engn & Mat Sci, Minneapolis, MN 55455 USA

[2] Soochow Univ, Dept Polymer Sci & Engn, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

来源：

PHYSICAL REVIEW LETTERS | 2013年 / 110卷 / 20期

关键词：

EXCLUDED-VOLUME; POLYMER-CHAINS; SCALING THEORY; MONTE-CARLO; SMALL PORES; STATISTICS; CROSSOVER; CHANNELS; DYNAMICS; LENGTH;

D O I：

10.1103/PhysRevLett.110.208103

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

DNA confinement in nanochannels is emerging as an important tool for genomics and an excellent platform for testing the theories of confined wormlike polymers. Using cutting-edge, large scale Monte Carlo simulations of asymptotically long wormlike chains, we show that, in analogy to the rod-to-coil transition for free wormlike polymers, there exists a universal, Gauss-de Gennes regime that connects the classic Odijk and de Gennes regimes of channel-confined chains. For DNA in a nanochannel, this Gauss-de Gennes regime spans practically the entire experimentally relevant range of channel sizes, including the nanochannels used in an incipient genome mapping technology.

引用

页数：5

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