Epigenetic alterations in cancer

被引：186

作者：

Ilango, Suganya ^{[1
]}

Paital, Biswaranjan ^{[2
]}

Jayachandran, Priyanka ^{[1
]}

Padma, Palghat Raghunathan ^{[1
]}

Nirmaladevi, Ramalingam ^{[1
]}

机构：

[1] Avinashilingam Inst Home Sci & Higher Educ Women, Dept Biochem Biotechnol & Bioinformat, Coimbatore 641043, Tamil Nadu, India

[2] Odisha Univ Agr & Technol, Dept Zool, Redox Regulat Lab, CBSH, Bhubaneswar 751003, Orissa, India

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2020年 / 25卷

关键词：

Epigenetics; Cancer; Hypoxia; DNA Methylation; Histone Modifications; miRNAs; Chromatin; HISTONE METHYLTRANSFERASE G9A; CPG ISLAND HYPERMETHYLATION; EMBRYONIC STEM-CELLS; DE-NOVO METHYLATION; DNA METHYLATION; LUNG-CANCER; HMLH1; PROMOTER; 5-METHYLCYTOSINE CONTENT; CHROMATIN MODIFICATIONS; SEQUENCE SPECIFICITY;

D O I：

10.2741/4847

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic and epigenetic modifications in such as DNA methylation, histone modifications, DNA contribute to altered gene expression in aging micro RNAs and nucleosome remodelling all control and cancer. In human cancers, epigenetic changes gene expression. The link between the genetics and epigenetics in cancer is further shown by existence of aberrant metabolism and biochemical pathways in cancer or mutation in genes that are epigenetic players. Reversal of these epigenetic changes has been clearly shown to have therapeutic value in various forms of lymphoma and preleukemia and similar results are appearing for the treatment of solid tumors. In this review, we discuss the functional effects of epigenetic changes inducible by hypoxia, the epigenetic alterations in cancer and how they contribute to tumor progression and their relevance to epigenetic therapy.

引用

页码：1058 / 1109

页数：52

共 238 条

[1] The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence [J].