Cytotoxic limonoids from the bark of Walsura cochinchinensis

被引：9

作者：

Trinh, Binh T. D. ^{[1
]}

Nguyen, Hiep D. ^{[2
]}

Nguyen, Hieu T. ^{[1
]}

Pham, Phuoc D. ^{[2
]}

Ngo, Ngoc T. N. ^{[1
]}

Nguyen, Le-Thu T. ^{[1
]}

Nguyen, Ly T. T. ^{[1
]}

Bui, Dzung N. ^{[1
]}

Dang, Son, V ^{[3
]}

Nguyen, Lien-Hoa D. ^{[1
]}

机构：

[1] Univ Sci, Fac Chem, VNU HCM, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam

[2] Ton Duc Thang Univ, Fac Pharm, 19 Nguyen Huu Tho, Ho Chi Minh City, Vietnam

[3] VAST, Inst Trop Biol, 85 Tran Quoc Toan, Ho Chi Minh City, Vietnam

来源：

FITOTERAPIA | 2019年 / 133卷

关键词：

Walsura cochinchinensis; Meliaceae; Limonoids; Phenolics; Cytotoxicity; 11-BETA-HSD1; INHIBITORS; REARRANGED LIMONOIDS; CHEMICAL-SHIFTS; TRITERPENOIDS; CONSTITUENTS; CHEMISTRY; ACID;

D O I：

10.1016/j.fitote.2018.11.008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new limonoids, walsucochinones A-C (1-3), along with eight known compounds, were isolated from an ethyl acetate extract of the bark of Walsura cochinchinensis. Their structures were determined using spectroscopic techniques, mainly 1-D and 2-D NMR. The ethyl acetate extract showed cytotoxic activity against MCF-7 human breast cancer cells and cytotoxicity of the isolated compounds were evaluated in vitro using the SRB assay. Walsucochinone C (3) exhibited the most active effect with IC50 value of 16.4 +/- 0.2 mu M.

引用

页码：75 / 79

页数：5

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