Reduced N-acetylaspartate in the hippocampus in patients with fibromyalgia: A meta-analysis

被引：20
作者：
Aoki, Yuta [1 ,2 ]
Inokuchi, Ryota [2 ,3 ]
Suwa, Hiroshi [1 ]
机构：
[1] Tokyo Metropolitan Hlth & Med Treatment Corp, Ebara Hosp, Dept Psychiat, Ota, Tokyo 1450065, Japan
[2] Tokyo Univ Hosp, Dept Emergency Med & Crit Care Med, Tokyo 1138655, Japan
[3] Univ Tokyo, Grad Sch Med, Dept Emergency & Crit Care Med, Tokyo 1138655, Japan
来源：
PSYCHIATRY RESEARCH-NEUROIMAGING | 2013年 / 213卷 / 03期
关键词：
Magnetic resonance spectroscopy (MRS); N-acetylaspartate (NAA); Pain; MAGNETIC-RESONANCE-SPECTROSCOPY; OBSESSIVE-COMPULSIVE DISORDER; GAMMA-AMINOBUTYRIC-ACID; GRAY-MATTER LOSS; METABOLITE ABNORMALITIES; BRAIN; PAIN; GLUTAMATE; GLUTAMATE/GLUTAMINE; DYSFUNCTION;
D O I：
10.1016/j.pscychresns.2013.03.008
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Fibromyalgia (FM) is a stress-associated syndrome with chronic, widespread pain. Patients with FM also present disturbances of cognition and memory. As the hippocampus is vulnerable to stress exposure and involved in cognition, memory and pain perception, we hypothesize that the abnormal function of the hippocampus is implicated in the pathophysiology of FM. N-acetylaspartate (NAA), a metabolite that can be measured using proton magnetic resonance spectroscopy (H-1 MRS), is recognized as a marker of neuronal structure and function. We performed a systematic review and meta-analysis of H-1 MRS studies investigating NAA levels in patients with FM. A comprehensive literature search through MEDLINE, Embase and Web of Science yielded nine studies; among these nine, four studies met our criteria for inclusion. A random effect model with 51 patients with FM and 38 controls revealed a significant NAA reduction in the hippocampus. The current meta-analysis suggested a neuronal abnormality in the hippocampus in patients with FM. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：242 / 248
页数：7
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