Combination Therapy in Hypertension

被引：22

作者：

Gorostidi, Manuel ^{[1
]}

de la Sierra, Alejandro ^{[2
]}

机构：

[1] Hosp Univ Cent Asturias, Dept Nephrol, Oviedo, Asturias, Spain

[2] Univ Barcelona, Dept Internal Med, Hosp Mutua Terrassa, Terrassa 08221, Spain

来源：

ADVANCES IN THERAPY | 2013年 / 30卷 / 04期

关键词：

Angiotensin-converting enzyme inhibitor; Antihypertensive treatment; Angiotensin-receptor blocker; Blood pressure control; Calcium channel blocker; Cardiology; Combination treatment; Hypertension; Renin-angiotensin blocker; CALCIUM-CHANNEL BLOCKER; ANGIOTENSIN-RECEPTOR BLOCKER; HIGH-BLOOD-PRESSURE; SINGLE-PILL COMBINATION; FIXED-DOSE COMBINATIONS; TO-SEVERE HYPERTENSION; DOUBLE-BLIND; RESISTANT HYPERTENSION; OLMESARTAN MEDOXOMIL; ADULT PATIENTS;

D O I：

10.1007/s12325-013-0020-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Hypertension is recognized as a major risk factor for cardiovascular and renal diseases and represents the leading cause of mortality worldwide. In spite of proven benefits of hypertension treatment, blood pressure control rates are poor, even in high-income countries with virtually full-access to therapies. Nearly 75% of hypertensive patients do not achieve adequate control with monotherapy, thus needing combination treatment. Strategies to improve blood pressure control include the prompt shift from monotherapy to combination therapy, the initial treatment with a two-drug combination, and the use of fixed-dose combinations in a single pill. Currently, preferred combinations include a renin-angiotensin blocker, either an angiotensin-converting enzyme inhibitor or an angiotensin-receptor blocker plus a calcium channel blocker or a diuretic. Some patients will also require a triple combination to achieve blood pressure control.

引用

页码：320 / 336

页数：17

共 82 条

[41] Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients [J].

Jamerson, Kenneth ;

Weber, Michael A. ;

Bakris, George L. ;

Dahlof, Bjorn ;

Pitt, Bertram ;

Shi, Victor ;

Hester, Allen ;

Gupte, Jitendra ;

Gatlin, Marjorie ;

Velazquez, Eric J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (23) :2417-2428

[42] Amlodipine/Valsartan Single-Pill Combination: a Prospective, Observational Evaluation of the Real-Life Safety and Effectiveness in the Routine Treatment of Hypertension [J].

Karpov, Yuri ;

Dongre, Neelesh ;

Vigdorchik, Alexey ;

Sastravaha, Krisada .

ADVANCES IN THERAPY, 2012, 29 (02) :134-147

[43] Fixed-dose manidipine/delapril versus losartan/hydrochlorothiazide in hypertensive patients with type 2 diabetes and microalbuminuria [J].

Kohlmann, Osvaldo, Jr. ;

Roca-Cusachs, Alejandro ;

Laurent, Stephane ;

Schmieder, Roland E. ;

Wenzel, Rene R. ;

Fogari, Roberto .

ADVANCES IN THERAPY, 2009, 26 (03) :313-324

[44] Clinic and ambulatory blood pressure lowering effect of aliskiren/amlodipine/hydrochlorothiazide combination in patients with moderate-to-severe hypertension: a randomized active-controlled trial [J].

Lacourciere, Yves ;

Taddei, Stefano ;

Konis, George ;

Fang, Hui ;

Severin, Thomas ;

Zhang, Jack .

JOURNAL OF HYPERTENSION, 2012, 30 (10) :2047-2055

[45] Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies [J].

Law, M. R. ;

Morris, J. K. ;

Wald, N. J. .

BMJ-BRITISH MEDICAL JOURNAL, 2009, 338 :1245

[46] Global burden of blood-pressure-related disease, 2001 [J].

Lawes, Carlene M. M. ;

Vander Hoorn, Stephen ;

Rodgers, Anthony .

LANCET, 2008, 371 (9623) :1513-1518

[47] A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010 [J].

Lim, Stephen S. ;

Vos, Theo ;

Flaxman, Abraham D. ;

Danaei, Goodarz ;

Shibuya, Kenji ;

Adair-Rohani, Heather ;

Amann, Markus ;

Anderson, H. Ross ;

Andrews, Kathryn G. ;

Aryee, Martin ;

Atkinson, Charles ;

Bacchus, Loraine J. ;

Bahalim, Adil N. ;

Balakrishnan, Kalpana ;

Balmes, John ;

Barker-Collo, Suzanne ;

Baxter, Amanda ;

Bell, Michelle L. ;

Blore, Jed D. ;

Blyth, Fiona ;

Bonner, Carissa ;

Borges, Guilherme ;

Bourne, Rupert ;

Boussinesq, Michel ;

Brauer, Michael ;

Brooks, Peter ;

Bruce, Nigel G. ;

Brunekreef, Bert ;

Bryan-Hancock, Claire ;

Bucello, Chiara ;

Buchbinder, Rachelle ;

Bull, Fiona ;

Burnett, Richard T. ;

Byers, Tim E. ;

Calabria, Bianca ;

Carapetis, Jonathan ;

Carnahan, Emily ;

Chafe, Zoe ;

Charlson, Fiona ;

Chen, Honglei ;

Chen, Jian Shen ;

Cheng, Andrew Tai-Ann ;

Child, Jennifer Christine ;

Cohen, Aaron ;

Colson, K. Ellicott ;

Cowie, Benjamin C. ;

Darby, Sarah ;

Darling, Susan ;

Davis, Adrian ;

Degenhardt, Louisa .

LANCET, 2012, 380 (9859) :2224-2260

[48] Combination of Amlodipine plus Angiotensin Receptor Blocker or Diuretics in High-Risk Hypertensive Patients A 96-Week Efficacy and Safety Study [J].

Ma, Liyuan ;

Wang, Wen ;

Zhao, Yong ;

Zhang, Yuqing ;

Deng, Qing ;

Liu, Mingbo ;

Sun, Hui ;

Wang, Jianchun ;

Liu, Lisheng .

AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS, 2012, 12 (02) :137-142

[49] Effect of Renin-Angiotensin System Blockade on Calcium Channel Blocker-Associated Peripheral Edema [J].

Makani, Harikrishna ;

Bangalore, Sripal ;

Romero, Jorge ;

Wever-Pinzon, Omar ;

Messerli, Franz H. .

AMERICAN JOURNAL OF MEDICINE, 2011, 124 (02) :128-135

[50] New-onset diabetes and anti hypertensive drugs [J].

Mancia, G ;

Grassi, G ;

Zanchetti, A .

JOURNAL OF HYPERTENSION, 2006, 24 (01) :3-10

← 1 2 3 4 5 6 7 8 9 →