Combination Therapy in Hypertension

被引：22

作者：

Gorostidi, Manuel ^{[1
]}

de la Sierra, Alejandro ^{[2
]}

机构：

[1] Hosp Univ Cent Asturias, Dept Nephrol, Oviedo, Asturias, Spain

[2] Univ Barcelona, Dept Internal Med, Hosp Mutua Terrassa, Terrassa 08221, Spain

来源：

ADVANCES IN THERAPY | 2013年 / 30卷 / 04期

关键词：

Angiotensin-converting enzyme inhibitor; Antihypertensive treatment; Angiotensin-receptor blocker; Blood pressure control; Calcium channel blocker; Cardiology; Combination treatment; Hypertension; Renin-angiotensin blocker; CALCIUM-CHANNEL BLOCKER; ANGIOTENSIN-RECEPTOR BLOCKER; HIGH-BLOOD-PRESSURE; SINGLE-PILL COMBINATION; FIXED-DOSE COMBINATIONS; TO-SEVERE HYPERTENSION; DOUBLE-BLIND; RESISTANT HYPERTENSION; OLMESARTAN MEDOXOMIL; ADULT PATIENTS;

D O I：

10.1007/s12325-013-0020-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Hypertension is recognized as a major risk factor for cardiovascular and renal diseases and represents the leading cause of mortality worldwide. In spite of proven benefits of hypertension treatment, blood pressure control rates are poor, even in high-income countries with virtually full-access to therapies. Nearly 75% of hypertensive patients do not achieve adequate control with monotherapy, thus needing combination treatment. Strategies to improve blood pressure control include the prompt shift from monotherapy to combination therapy, the initial treatment with a two-drug combination, and the use of fixed-dose combinations in a single pill. Currently, preferred combinations include a renin-angiotensin blocker, either an angiotensin-converting enzyme inhibitor or an angiotensin-receptor blocker plus a calcium channel blocker or a diuretic. Some patients will also require a triple combination to achieve blood pressure control.

引用

页码：320 / 336

页数：17

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