Progress to Date in the Design and Operation of Continuous Crystallization Processes for Pharmaceutical Applications

被引：113

作者：

Wood, Barbara ^{[1
,2
]}

Girard, Kevin P. ^{[3
]}

Polster, Christopher S. ^{[4
]}

Croker, Denise M. ^{[1
,2
]}

机构：

[1] Univ Limerick, Bernal Inst, Dept Chem Sci, Limerick, Ireland

[2] Univ Limerick, Bernal Inst, Synth & Solid State Pharmaceut Ctr SSPC, Limerick, Ireland

[3] Pfizer, Worldwide Res & Dev, Chem Res & Dev, Groton, CT 06340 USA

[4] Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Small Mol Design & Dev, Indianapolis, IN 46285 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2019年 / 23卷 / 02期

关键词：

continuous crystallization; pharmaceutical manufacturing; MSMPR crystallization; COBC; plug flow crystallizers; CONTINUOUS MIXED-SUSPENSION; PLUG-FLOW CRYSTALLIZATION; MSMPR CRYSTALLIZATION; PARTICLE-SIZE; ADIPIC ACID; SCALE-UP; REMOVAL; BATCH; MODEL; PARACETAMOL;

D O I：

10.1021/acs.oprd.8b00319

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Continuous crystallization has gained interest in the pharmaceutical sector as part of the drive toward the transition from exclusive batch manufacturing to integrated continuous manufacturing in this industry. As a result, the design and operation of continuous crystallization processes for the preparation of pharmaceutical materials has been featured strongly in recent scientific literature. This review is an effort to gather together all of the published understanding on continuous crystallization with a pharmaceutical focus and to benchmark progress to date in realizing the potential benefits of transitioning this stalwart pharmaceutical unit operation from batch to continuous configurations.

引用

页码：122 / 144

页数：23

共 95 条

[1] Evaluation of mixed suspension mixed product removal crystallization processes coupled with a continuous filtration system [J].

Acevedo, David ;

Pena, Ramon ;

Yang, Yang ;

Barton, Alastair ;

Firth, Paul ;

Nagy, Zoltan K. .

CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION, 2016, 108 :212-219

[2] Continuous Crystallization of Paracetamol (Acetaminophen) Form II: Selective Access to a Metastable Solid Form [J].

Agnew, Lauren R. ;

McGlone, Thomas ;

Wheatcroft, Helen P. ;

Robertson, Amy ;

Parsons, Anna R. ;

Wilson, Chick C. .

CRYSTAL GROWTH & DESIGN, 2017, 17 (05) :2418-2427

[3] Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment [J].

Agnew, Lauren R. ;

Cruickshank, Dyanne L. ;

McGlone, Thomas ;

Wilson, Chick C. .

CHEMICAL COMMUNICATIONS, 2016, 52 (46) :7368-7371

[4] Crystallization of Cyclosporine in a Multistage Continuous MSMPR Crystallizer [J].

Alvarez, Alejandro J. ;

Singh, Aniruddh ;

Myerson, Allan S. .

CRYSTAL GROWTH & DESIGN, 2011, 11 (10) :4392-4400

[5] Continuous Plug Flow Crystallization of Pharmaceutical Compounds [J].

Alvarez, Alejandro J. ;

Myerson, Allan S. .

CRYSTAL GROWTH & DESIGN, 2010, 10 (05) :2219-2228

[6]

[Anonymous], 2004, PAT FRAM INN PHARM

[7] A Plant-Wide Dynamic Model of a Continuous Pharmaceutical Process [J].

Benyahia, Brahim ;

Lakerveld, Richard ;

Barton, Paul I. .

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2012, 51 (47) :15393-15412

[8] Multi-Impurity Adsorption Model for Modeling Crystal Purity and Shape Evolution during Crystallization Processes in Impure Media [J].

Borsos, Akos ;

Majumder, Aniruddha ;

Nagy, Zoltan K. .

CRYSTAL GROWTH & DESIGN, 2016, 16 (02) :555-568

[9] Seeded Crystallization of β-L-Glutamic Acid in a Continuous Oscillatory Baffled Crystallizer [J].

Briggs, Naomi E. B. ;

Schacht, Ulrich ;

Raval, Vishal ;

McGlone, Thomas ;

Sefcik, Jan ;

Florence, Alastair J. .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2015, 19 (12) :1903-1911

[10] Evaluation of crystallization kinetics of adipic acid in an oscillatory baffled crystallizer [J].

Brown, C. J. ;

Lee, Y. C. ;

Nagy, Z. K. ;

Ni, X. .

CRYSTENGCOMM, 2014, 16 (34) :8008-8014

← 1 2 3 4 5 6 7 8 9 10 →