Synthesis of Chiral Amino Acid Anilides by Ligand-Free Copper-Catalyzed Selective N-Arylation of Amino Acid Amides

被引：29

作者：

Dong, Junyu ^{[1
]}

Wang, Yan ^{[1
]}

Xiang, Qinjie ^{[1
]}

Lv, Xirui ^{[1
]}

Weng, Wen ^{[2
]}

Zeng, Qingle ^{[1
]}

机构：

[1] Chengdu Univ Technol, Inst Green Catalysis & Synth, Coll Mat & Chem & Chem Engn, Chengdu 610059, Peoples R China

[2] Zhangzhou Normal Univ, Dept Chem & Environm Sci, Zhangzhou 363000, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 04期

关键词：

amino acid amides; amino acid anilides; chiral pool; copper; cross-coupling; TRANSFER HYDROGENATION REACTION; C-N; COUPLING REACTIONS; METAL-COMPLEXES; ARYL; AMINATION; FUNCTIONALIZATION; AMIDATION; PROLINE; ANALOGS;

D O I：

10.1002/adsc.201200752

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An atom-economic, practical and cost-effective protocol for synthesis of chiral amino acid anilides via ligand-free copper-catalyzed selective CN cross coupling of chiral amino acid amides and aryl halides, hetereoaryl halides and a vinyl bromide has been developed. No racemization occurred during the CN coupling. A plausible mechanism is proposed.

引用

页码：692 / 696

页数：5

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