Epidemiological Interpretation of Studies Examining the Effect of Antibiotic Usage on Resistance

被引:135
作者
Schechner, Vered [1 ]
Temkin, Elizabeth [1 ,2 ]
Harbarth, Stephan [3 ,4 ,5 ]
Carmeli, Yehuda [1 ,2 ]
Schwaber, Mitchell J. [2 ]
机构
[1] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Div Epidemiol & Prevent Med, IL-69978 Tel Aviv, Israel
[2] Israel Minist Hlth, Natl Ctr Infect Control, Tel Aviv, Israel
[3] Univ Hosp Geneva, Div Infect Dis, Geneva, Switzerland
[4] Univ Hosp Geneva, Infect Control Program, Geneva, Switzerland
[5] Univ Geneva, Sch Med, CH-1211 Geneva, Switzerland
关键词
GRAM-NEGATIVE BACILLI; INTENSIVE-CARE UNITS; LACTAMASE-PRODUCING ENTEROBACTERIACEAE; URINARY-TRACT-INFECTION; BROAD-SPECTRUM CEPHALOSPORIN; STAPHYLOCOCCUS-AUREUS MRSA; AERUGINOSA RISK-FACTORS; ANTIBACTERIAL DRUG-USE; NESTED CASE-CONTROL; PSEUDOMONAS-AERUGINOSA;
D O I
10.1128/CMR.00001-13
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Bacterial resistance to antibiotics is a growing clinical problem and public health threat. Antibiotic use is a known risk factor for the emergence of antibiotic resistance, but demonstrating the causal link between antibiotic use and resistance is challenging. This review describes different study designs for assessing the association between antibiotic use and resistance and discusses strengths and limitations of each. Approaches to measuring antibiotic use and antibiotic resistance are presented. Important methodological issues such as confounding, establishing temporality, and control group selection are examined.
引用
收藏
页码:289 / 307
页数:19
相关论文
共 192 条
[91]   Prior antibiotics and risk of antibiotic-resistant community-acquired urinary tract infection: a case-control study [J].
Hillier, Sharon ;
Roberts, Zoe ;
Dunstan, Frank ;
Butler, Chris ;
Howard, Anthony ;
Palmer, Stephen .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 60 (01) :92-99
[92]   Fluoroquinolone-resistant Pseudomonas aeruginosa:: risk factors for acquisition and impact on outcomes [J].
Hsu, DI ;
Okamoto, MP ;
Murthy, R ;
Wong-Beringer, A .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 55 (04) :535-541
[93]   Carbapenem Resistance Among Klebsiella pneumoniae Isolates: Risk Factors, Molecular Characteristics, and Susceptibility Patterns [J].
Hussein, Khetam ;
Sprecher, Hanna ;
Mashiach, Tania ;
Oren, Ilana ;
Kassis, Imad ;
Finkelstein, Renato .
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2009, 30 (07) :666-671
[94]   Ertapenem-Resistant Enterobacteriaceae: Risk Factors for Acquisition and Outcomes [J].
Hyle, E. P. ;
Ferraro, M. J. ;
Silver, M. ;
Lee, H. ;
Hooper, D. C. .
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2010, 31 (12) :1242-1249
[95]   Use of different thresholds of prior antimicrobial use in defining exposure: Impact on the association between antimicrobial use and antimicrobial resistance [J].
Hyle, Emily P. ;
Gasink, Leanne B. ;
Linkin, Darren R. ;
Bilker, Warren B. ;
Lautenbach, Ebbing .
JOURNAL OF INFECTION, 2007, 55 (05) :414-418
[96]   Impact of different methods for describing the extent of prior antibiotic exposure on the association between antibiotic use and antibiotic-resistant infection [J].
Hyle, Emily P. ;
Bilker, Warren B. ;
Gasink, Leanne B. ;
Lautenbach, Ebbing .
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2007, 28 (06) :647-654
[97]  
Jessop AB, 1998, INFECT CONT HOSP EP, V19, P186, DOI 10.1086/647792
[98]   Emergence of fluoroquinolone resistance in outpatient urinary Escherichia coli isolates [J].
Johnson, Luke ;
Sabel, Allison ;
Burman, William J. ;
Everhart, Rachel M. ;
Rome, Marcie ;
MacKenzie, Thomas D. ;
Rozwadowski, Jeanne ;
Mehler, Philip S. ;
Price, Connie Savor .
AMERICAN JOURNAL OF MEDICINE, 2008, 121 (10) :876-884
[99]   Acquisition of imipenem-resistant Acinetobacter baumannii in a pediatric intensive care unit:: a case-control study [J].
Katragkou, Aspasia ;
Kotsiou, Maria ;
Antachopoulos, Charalampos ;
Benos, Alexis ;
Sofianou, Danai ;
Tamiolaki, Maria ;
Roilides, Emmanuel .
INTENSIVE CARE MEDICINE, 2006, 32 (09) :1384-1391
[100]   Differential effects of levofloxacin and ciprofloxacin on the risk for isolation of quinolone-resistant Pseudomonas aeruginosa [J].
Kaye, KS ;
Kanafani, ZA ;
Dodds, AE ;
Engemann, JJ ;
Weber, SG ;
Carmeli, Y .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (06) :2192-2196