Age-related impairment of pancreatic beta-cell function: pathophysiological and cellular mechanisms

被引：87
作者：
De Tata, Vincenzo [1 ]
机构：
[1] Univ Pisa, Dept Translat Res & New Technol Med & Surg, Via Roma,55 Scuola Med, I-56126 Pisa, Italy
来源：
FRONTIERS IN ENDOCRINOLOGY | 2014年 / 5卷
关键词：
aging; pancreatic beta cells; insulin secretion; insulin resistance; cellular senescence; GENOME-WIDE ASSOCIATION; GLUCAGON-LIKE PEPTIDE-1; INSULIN SECRETORY FUNCTION; GLYCATION END-PRODUCTS; GLUCOSE-HOMEOSTASIS; DIABETES-MELLITUS; LIFE-STYLE; INK4A/ARF EXPRESSION; CYCLE INHIBITORS; NATIONAL-HEALTH;
D O I：
10.3389/fendo.2014.00138
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The incidence of type 2 diabetes significantly increases with age. The relevance of this association is dramatically magnified by the concomitant global aging of the population, but the underlying mechanisms remain to be fully elucidated. Here, some recent advances in this field are reviewed at the level of both the pathophysiology of glucose homeostasis and the cellular senescence of pancreatic islets. Overall, recent results highlight the crucial role of beta-cell dysfunction in the age-related impairment of pancreatic endocrine function and delineate the possibility of new original therapeutic interventions.
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页数：8
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