Shedding light onto live molecular targets

被引：1548

作者：

Weissleder, Ralph ^{[1
]}

Ntziachristos, Vasilis

机构：

[1] Massachusetts Gen Hosp, Ctr Mol Imaging Res, Charlestown, MA USA

来源：

NATURE MEDICINE | 2003年 / 9卷 / 01期

关键词：

D O I：

10.1038/nm0103-123

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Optical sensing of specific molecular targets and pathways deep inside living mice has become possible as a result of a number of advances. These include design of biocompatible near-infrared fluorochromes, development of targeted and activatable 'smart' imaging probes, engineered photoproteins and advances in photon migration theory and reconstruction. Together, these advances will provide new tools making it possible to understand more fully the functioning of protein networks, diagnose disease earlier and speed along drug discovery.

引用

页码：123 / 128

页数：6

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