Relation Between Mean Platelet Volume and Severity of Atherosclerosis in Patients With Acute Coronary Syndromes

被引：56

作者：

Murat, Sani Namik ^{[1
]}

Duran, Mustafa ^{[2
]}

Kalay, Nihat ^{[3
]}

Gunebakmaz, Ozgur ^{[4
]}

Akpek, Mahmut ^{[3
]}

Doger, Cihan ^{[1
]}

Elcik, Deniz ^{[3
]}

Ocak, Ayse ^{[3
]}

Vatankulu, Mehmet Akif ^{[5
]}

Turfan, Murat ^{[5
]}

Kasapkara, Haci Ahmet ^{[6
]}

Akin, Fatih ^{[2
]}

Sahin, Musa ^{[7
]}

Kaya, Mehmet Gungor ^{[3
]}

机构：

[1] Etlik Ihtisas Res & Educ Hosp, Ankara, Turkey

[2] Kayseri Res & Educ Hosp, Kayseri, Turkey

[3] Erciyes Univ, Fac Med, Kayseri, Turkey

[4] Kastamonu City Hosp, Kastamonu, Turkey

[5] Bezmialem Univ, Fac Med, Istanbul, Turkey

[6] Ataturk Res & Educ Hosp, Ankara, Turkey

[7] Yuzuncu Yil Univ, Fac Med, Van, Turkey

来源：

ANGIOLOGY | 2013年 / 64卷 / 02期

关键词：

mean platelet volume; acute coronary syndrome; Gensini score; Syntax score; INDEPENDENT RISK FACTOR; MYOCARDIAL-INFARCTION; ARTERY-DISEASE; UNSTABLE ANGINA; HEART-DISEASE; INDEXES; SUBPOPULATIONS; INFLAMMATION; ACTIVATION; SCORE;

D O I：

10.1177/0003319711436247

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Platelets play a central role in the pathophysiology of coronary artery disease (CAD). Increased mean platelet volume (MPV) is an indicator of platelet function and associated with poor clinical outcome in patients with acute coronary syndrome (ACS). We evaluated the relationship between MPV and severity of CAD in patients with ACS. A total of 395 patients with ACS were included. Severity of CAD was assessed with the Gensini and Syntax scores. High levels of MPV were associated with the Gensini and Syntax scores, number of diseased vessels (> 50%), number of critical lesions (> 50% and > 70%), and noncritical lesions. After multivariate analysis, high levels of MPV were independent predictors of multivessel CAD together with age. In patients with ACS, high MPV levels were associated with severity of CAD. It is possible that MPV can be a helpful marker in patients with CAD for the severity of coronary atherosclerosis.

引用

页码：131 / 136

页数：6

共 29 条

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