Red blood cells as carriers in magnetic particle imaging

被引：30

作者：

Antonelli, Antonella ^{[1
]}

Sfara, Carla ^{[1
]}

Rahmer, Juergen ^{[2
]}

Gleich, Bernhard ^{[2
]}

Borgert, Joern ^{[2
]}

Magnani, Mauro ^{[1
]}

机构：

[1] Univ Urbino Carlo Bo, Dept Biomol Sci, I-61029 Urbino, Italy

[2] Philips Technol GmbH, Innovat Technol, Res Labs, D-22315 Hamburg, Germany

来源：

BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK | 2013年 / 58卷 / 06期

关键词：

carriers; MPI; red blood cells; SPIO nanoparticles; SUPERPARAMAGNETIC IRON-OXIDE; CONTRAST AGENTS; LOADED ERYTHROCYTES; NANOPARTICLES; LIVER; MRI; ENHANCEMENT; RESOVIST(R);

D O I：

10.1515/bmt-2012-0065

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Red blood cells (RBCs) represent intravascular carriers for drugs, biologics, and other therapeutic agents, characterized by their unique longevity in the bloodstream, availability, considerable surface and volume, high biocompatibility, and natural mechanisms for safe elimination. Recently, the potential of RBCs loaded with superparamagnetic iron oxide (SPIO) nanoparticles as a tracer material for magnetic particle imaging (MPI) to realize a blood-pool tracer agent with longer blood retention time for imaging of the circulatory system, has been investigated. MPI is a new tomographic imaging approach that can quantitatively map magnetic nanoparticle distributions in vivo. However, SPIO contrast agents, such as Resovist, have a short blood half-life due to rapid uptake by the reticuloendothelial system, which limits the applicability of such compounds for certain applications such as long-term monitoring. Here, we report the in vitro magnetic characterization study of human SPIO-loaded RBCs and the first MPI results obtained after intravenous injection of murine SPIO-loaded RBCs in an in vivo MPI experiment.

引用

页码：517 / 525

页数：9

共 37 条

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