Ultrastructural localization of actin and actin-binding proteins in the nucleus

被引：43

作者：

Dingova, Hana ^{[1
]}

Fukalova, Jana ^{[1
]}

Maninova, Miloslava ^{[1
]}

Philimonenko, Vlada V. ^{[1
]}

Hozak, Pavel ^{[1
]}

机构：

[1] Acad Sci Czech Republic, Inst Mol Genet VVI, Prague 14220 4, Czech Republic

来源：

HISTOCHEMISTRY AND CELL BIOLOGY | 2009年 / 131卷 / 03期

关键词：

Nuclear actin; Ultrastructure; Actin-binding proteins; POLYMERASE-I TRANSCRIPTION; XENOPUS-LAEVIS PAXILLIN; INTERSTRAND CROSS-LINKS; ARP2/3; COMPLEX; MYOSIN-I; POLY(A)-BINDING PROTEIN-1; CELLULAR COMPARTMENTS; ANDROGEN RECEPTOR; SPECTRIN REPEAT; BETA-ACTIN;

D O I：

10.1007/s00418-008-0539-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nuclear actin plays an important role in such processes as chromatin remodeling, transcriptional regulation, RNA processing, and nuclear export. Recent research has demonstrated that actin in the nucleus probably exists in dynamic equilibrium between monomeric and polymeric forms, and some of the actin-binding proteins, known to regulate actin dynamics in cytoplasm, have been also shown to be present in the nucleus. In this paper, we present ultrastructural data on distribution of actin and various actin-binding proteins (alpha-actinin, filamin, p190RhoGAP, paxillin, spectrin, and tropomyosin) in nuclei of HeLa cells and resting human lymphocytes. Probing extracts of HeLa cells for the presence of actin-binding proteins also confirmed their presence in nuclei. We report for the first time the presence of tropomyosin and p190RhoGAP in the cell nucleus, and the spatial colocalization of actin with spectrin, paxillin, and alpha-actinin in the nucleolus.

引用

页码：425 / 434

页数：10

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