Biological macromolecules based targeted nanodrug delivery systems for the treatment of intracellular infections

被引：13
作者：
Aparna, V. [1 ]
Shiva, M. [1 ]
Biswas, Raja [1 ]
Jayakumar, R. [1 ]
机构：
[1] Amrita Vishwa Vidyapeetham, Amrita Inst Med Sci & Res Ctr, Amrita Ctr Nanosci & Mol Med, Kochi 682041, Kerala, India
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2018年 / 110卷
关键词：
Targeted drug delivery; Macrophage targeting; Intracellular infections; Drug delivery; Biological macromolecules; Nanoparticles; PHAGOSOME-LYSOSOME FUSION; MESOPOROUS SILICA NANOPARTICLES; MYCOBACTERIUM-TUBERCULOSIS; ANTITUBERCULOSIS DRUGS; LEGIONELLA-PNEUMOPHILA; BACTERIAL-INFECTIONS; BRUCELLA-ABORTUS; IN-VITRO; MACROPHAGES; ANTIBIOTICS;
D O I：
10.1016/j.ijbiomac.2018.01.030
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Intracellular infections are tricky to treat, the reason being the poor penetration of antibiotics/antimycotics into the microbial niche (host cell). Macrophages are primary targets of facultative and obligate intracellular bacteria/fungi to be abused as host cells. The need for drugs with better intracellular penetration led to the development of endocytosable drug carriers, which can cross the cell membrane of the host cells (macrophages) by imitating the entry path of the pathogens. Therefore, the drugs can be targeted to macrophages ensuring enhanced therapeutic effect. This review discusses the exploitation of various nanocarriers for targeted delivery of drugs to the macrophages in the last two decades. (C) 2018 Elsevier B.V. All rights reserved.
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收藏
页码：2 / 6
页数：5
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