PEGylation and Zwitterionization: Pros and Cons in the Renal Clearance and Tumor Targeting of Near-IR-Emitting Gold Nanoparticles

被引：215

作者：

Liu, Jinbin ^{[1
]}

Yu, Mengxiao ^{[1
]}

Ning, Xuhui ^{[1
]}

Zhou, Chen ^{[1
]}

Yang, Shengyang ^{[1
]}

Zheng, Jie ^{[1
]}

机构：

[1] Univ Texas Dallas, Dept Chem, Richardson, TX 75080 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 48期

关键词：

nanoparticles; PEGylation; renal clearance; surface chemistry; tumor targeting; MESOPOROUS SILICA NANOPARTICLES; IN-VIVO; QUANTUM DOTS; ENHANCED PERMEABILITY; CANCER-CHEMOTHERAPY; URINARY-EXCRETION; PARTICLE-SIZE; BIODISTRIBUTION; MICE; RETENTION;

D O I：

10.1002/anie.201304465

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Got it PEGged: PEGylation and zwitterionization have distinct effects on the pharmacokinetic and tumor-targeting properties of luminescent gold nanoparticles (AuNPs), although both strategies lead to effective renal clearance. High tumor-targeting efficiency and specificity were obtained with PEGylated AuNPs, whereas rapid tumor detection was more readily achieved with zwitterionic AuNPs. HD=hydrodynamic diameter, GS=glutathione. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：12572 / 12576

页数：5

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