Synthesis and Antibacterial Activities of Myricetin Derivatives Containing Acidamide Moiety

被引：10

作者：

Xiao Wei ^{[1
]}

Ruan Xianghui ^{[1
]}

Li Qin ^{[1
]}

Zhang Juping ^{[1
]}

Zhong Xinmin ^{[1
]}

Xie Yan ^{[1
]}

Wang Xiaobin ^{[1
]}

Huang Minguo ^{[1
]}

Xue Wei ^{[1
]}

机构：

[1] Guizhou Univ, Ctr Res & Dev Fine Chem, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn,Minist Educ, Guiyang 550025, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2017年 / 38卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Myricetin derivatives; Acidamide; Antibacterial activity; BIOLOGICAL-ACTIVITY; FLAVONOIDS; BIOACTIVITY; INHIBITION; DESIGN;

D O I：

10.7503/cjcu20160654

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Twelve novel myricetin derivatives containing acidamide moiety were designed and synthesized from myricetin. All the compounds were characterized by H-1 NMR, C-13 NMR and HRMS. The preliminary bioassay results indicated that all of the title compounds exhibited a certain antibacterial activities in vitro against X. oryzae, X. citri and R. solanacearum. Moreover, These title compounds 3a, 3e, 3f, 3h and 3k displayed good antibacterial activities against the above three plant pathogenic bacteria. Especially, compound 3e displayed 100% inhibition rates against X. oryzae and R. solanacearum at 200 mu g/mL, respectively, which is more than the control bismerthiazol ( 72. 85% and 75. 86%, repectively ).

引用

页码：35 / 40

页数：6

共 32 条

[21]

Wei TB, 2007, INDIAN J CHEM B, V46, P880

[22]

Wu Y. C., 2015, STUDIES SYNTHESIS AP

[23]

Xie K. Z., 2010, Preparation of Cinnamic Acid Derivatives Useful in the Treatment of Cardiovascular and Cerebrovascular Diseases, Patent No. [CN 101928265B, 101928265]

[24] Synthesis and Biological Activity of Novel Dicyano-containning Cyclopropane-1-carboxamides [J].

Xu Gaofei ;

Liu Yanhong ;

Yang Xinling ;

Wang Daoquan ;

Yuan Dekai .

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2016, 37 (03) :486-492

[25]

Xu Q., 2005, WORLD CHIN J DIGESTO, V13, P2082

[26] Inhibition of Tobacco Bacterial Wilt with Sulfone Derivatives Containing an 1,3,4-Oxadiazole Moiety [J].

Xu, Wei-Ming ;

Han, Fei-Fei ;

He, Ming ;

Hu, De-Yu ;

He, Jiang ;

Yang, Song ;

Song, Bao-An .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2012, 60 (04) :1036-1041

[27] Novel myricetin derivatives: Design, synthesis and anticancer activity [J].

Xue, Wei ;

Song, Bao-An ;

Zhao, Hong Ju ;

Qi, Xing Bao ;

Huang, Yin Jiu ;

Liu, Xin Hua .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 97 :155-163

[28] A Facile C-N Bond Formation: One-Pot Reaction of Phenols and Amines via Smiles Rearrangement [J].

Yang, Hao ;

Li, Zhu-Bo ;

Shin, Dong-Soo ;

Wang, Li-Ying ;

Zhou, Jia-Zhou ;

Qiao, Hong-Bo ;

Tian, Xiao ;

Ma, Xiao-Yan ;

Zuo, Hua .

SYNLETT, 2010, (03) :483-487

[29]

Zhou JR, 1998, CANCER RES, V58, P5231

[30]

Zhu J. D., 1998, FOREIGN MED SCI HYGE, V25, P257

← 1 2 3 4 →